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NCT06580899
Intra-Articular Catheter Total Knee Arthroplasty
Phase 4 trial testing Intra-articular catheter in Continuous Local Infiltration Analgesia in 65 participants. Enrolling by invitation.
1 September 2026
Quick facts
| Lead sponsor | OrthoCarolina Research Institute, Inc. |
|---|---|
| Phase | Phase 4 |
| Status | ENROLLING BY INVITATION |
| Study type | INTERVENTIONAL |
| Allocation | randomized |
| Design | parallel |
| Masking | none |
| Primary purpose | supportive care |
| Enrollment | 65 |
| Start date | 14 March 2025 |
| Primary completion | 1 September 2026 |
| Estimated completion | 31 December 2026 |
| Sites | 1 location across United States |
Drugs / interventions tested
- Intra-articular catheter
- Routine Standard of Care Treatment
Conditions studied
- Continuous Local Infiltration Analgesia — all drugs for Continuous Local Infiltration Analgesia →
- Intra-articular Catheter — all drugs for Intra-articular Catheter →
- Total Knee Arthroplasty — all drugs for Total Knee Arthroplasty →
Sponsor
OrthoCarolina Research Institute, Inc.
Who can join
18 and older, any sex, with Continuous Local Infiltration Analgesia or Intra-articular Catheter. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
This is a prospective, randomized clinical trial evaluating three groups. The groups are: Group 1 (Control): Subjects that receive only the existing standard-of-care multimodal pain management protocol and do not receive post-operative intra-articular catheter. Group 2 (Investigational Treatment/Intervention): Subjects that receive the brand 1 intra-articular catheter pump with existing standard-of-care multimodal pain management protocol in the immediate post-operative period. Group 3 (Investigational Treatment/Intervention): Subjects that receive the newer brand 2 intra-articular catheter pump with existing standard-of-care multimodal pain management protocol in the immediate post-operative period.
Publications & conference data
No peer-reviewed publications indexed yet for this trial.
Verify or expand the search:
- PubMed search for NCT06580899
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
Related trials
Other OrthoCarolina Research Institute, Inc. trials
Trials by the same sponsor.
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- NCT06935331 — Prospective Opioid-Free AIS Fusion · Phase 4 · enrolling by invitation
- NCT05931627 — Tourniquet Use in Anterior Cruciate Ligament Repair · NA · enrolling by invitation
- NCT04513145 — Adductor Canal Block · Phase 2, PHASE3 · terminated
Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT06580899 (US National Library of Medicine, public domain)
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by OrthoCarolina Research Institute, Inc.
- Last refreshed: 6 April 2026
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT06580899.
Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing