Last reviewed · How we verify
NCT06579807
Cardiac Rehabilitation and Coronary Artery Disease
NA trial testing Exercise training in Coronary Artery Disease in 50 participants. Currently enrolling.
31 December 2026
Quick facts
| Lead sponsor | Instituto Nacional de Cardiologia de Laranjeiras |
|---|---|
| Phase | NA |
| Status | Recruiting now |
| Study type | INTERVENTIONAL |
| Allocation | non randomized |
| Design | parallel |
| Masking | single |
| Primary purpose | supportive care |
| Enrollment | 50 |
| Start date | 1 October 2024 |
| Primary completion | 31 December 2026 |
| Estimated completion | 31 December 2026 |
| Sites | 1 location across Brazil |
Drugs / interventions tested
- Exercise training
Conditions studied
- Coronary Artery Disease — all drugs for Coronary Artery Disease →
- Atherosclerosis — all drugs for Atherosclerosis →
Sponsor
Instituto Nacional de Cardiologia de Laranjeiras
Who can join
Adults 40 to 70, any sex, with Coronary Artery Disease or Atherosclerosis. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
Patients with coronary artery disease (CAD) aged 40-70 years will undergo exercise training (thrice weekly for 12 weeks). A reference group composed of healthy individuals will be included. Evaluations will be conducted at baseline and after the intervention period during two visits. During the first visit, carotid artery thickness will be assessed via ultrasound before and after a cardiopulmonary exercise testing. The second visit will include the evaluation of endothelial function using venous occlusion plethysmography. After this, participants will engage in 30 minutes of moderate-intensity aerobic exercise, and blood samples will be collected pre- and post-exercise. Circulating levels of kynurenine pathway (KP) metabolites (Tryptophan, kynurenine, kynurenic acid, and quinolinic acid), pro-inflammatory cytokines, cell adhesion molecules, and lipid profiles will be measured via Enzyme-Linked Immunosorbent Assay (ELISA), multiplex essays, and biochemical analysis; respectively.
Publications & conference data
2 peer-reviewed publications reference this trial (live from Europe PMC):
-
Acute and chronic effects of physical exercise on atherosclerosis, kynurenine pathway, endothelial function and inflammation in patients with coronary artery disease: a clinical trial protocol.
Paz GA, Rangel MV, Farias CL, Soares ALC, et al · · 2025 · cited 3× · PMID 39944998 · DOI 10.1136/bmjsem-2024-002432 -
Kynurenine as a Predictor of Long-Term Mortality: A 10-Year Follow-Up from the KORONEF Registry.
Kern A, Stompór T, Bojko K, Sienkiewicz E, et al · · 2025 · cited 1× · PMID 40426950 · DOI 10.3390/biomedicines13051123
Verify or expand the search:
- PubMed search for NCT06579807
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
Related trials
Other trials of Exercise training
Trials testing the same drug.
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- NCT07513987 — IMPACT: Immune and Musculoskeletal Physiological Adaptations to Combined Exercise Training & Nutrition · NA · not yet recruiting
- NCT06650995 — AlEX-DHF: Ablation and Exercise in Diastolic Heart Failure · NA · recruiting
- NCT07341711 — Long-term Adaptations of Skeletal Muscle After Hybrid Training. · NA · not yet recruiting
- NCT07300332 — Exercise Training and Vitamin D Metabolism · NA · recruiting
Other recruiting trials for Coronary Artery Disease
Currently open trials in the same condition.
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- NCT07286578 — A Prospective, Multicenter, Randomized Controlled Trial to Investigate the Value of Coronary CT Angiography in the Under · NA · recruiting
Other Instituto Nacional de Cardiologia de Laranjeiras trials
Trials by the same sponsor.
- NCT04512456 — Cardiovascular Responses to Exercise in People Living With HIV/AIDS: Effects of Exercise Training · NA · recruiting
- NCT04766554 — Cerebral Oxygen Saturation Monitoring In Cardiac Surgery (COSMICS) · NA · completed
- NCT03343522 — The Effects of Exercise Training in Vascular Function of Patients Living With HIV · NA · completed
Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT06579807 (US National Library of Medicine, public domain)
- Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by Instituto Nacional de Cardiologia de Laranjeiras
- Last refreshed: 27 March 2026
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT06579807.
Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing