Who is sponsoring NCT06579066?

NCT06579066 is sponsored by Ain Shams University.

What condition does NCT06579066 study?

NCT06579066 studies Chronic Kidney Disease, Uremic Pruritus.

What drugs are being tested in NCT06579066?

Interventions: Probiotic Blend Capsule, Activated Charcoal.

What is the status of NCT06579066?

NCT06579066 is currently NOT_YET_RECRUITING.

Last reviewed 2024-08-28 · How we verify

The Effect of Probiotics Versus Activated Charcoal in the Management of Chronic Kidney Disease Patients Suffering From Uremic Pruritus.

NCT06579066 Phase 2 NOT_YET_RECRUITING

This study aims to evaluate the efficacy and safety of probiotics versus activated charcoal in management of chronic kidney disease patients suffering from uremic pruritus. Patient data collection Demographic data:The following data will be collected from the patient records; including age, sex, weight, height. History Taking :Including patient's medical history, past surgical history, family medical history, and medications the patient is taking or may have recently stopped taking. A patient's medical history may also include information about allergies, etiology of uremic pruritus. Laboratory examinations:The following laboratory data to be measured at baseline and after the duration of treatment (4 weeks) 1. Serum levels of indoxyl sulfate (IS) 2. Kidney Function tests: BUN, Creatinine 3. Electrolytes test: sodium, potassium, chloride ,ionized calcium, phosphorus Dermatological examination: Base on 1. measure Visual Analoge Scale Score(VAS). 2. measure Dermatology life quality index (DLQI).

Details

Lead sponsor	Ain Shams University
Phase	Phase 2
Status	NOT_YET_RECRUITING
Enrolment	123
Start date	2024-09
Completion	2025-03

Conditions

Chronic Kidney Disease
Uremic Pruritus

Interventions

Probiotic Blend Capsule
Activated Charcoal

Primary outcomes

Change in serum Indoxyl sulfate (IS) level — Four weeks
IS is one of the most potent protein bound uremic toxins . mesasuring serum indoxyl sulfate level at baseline and after a 4 weeks trial period by using ELISA kits.
Change in visual Analog scale (VAS) score. — Four weeks
A 10 cm horizontal line marked from zero (no pruritus) to 10 (worst possible pruritus). The pruritus will be assessed subjectively and scored at baseline and after a 4 weeks trial period .
Change in Dermatology life quality index (DLQI) — Four weeks
10-Item questionnaire aiming to measure how much skin problem has affected on QOL . mesasuring DLQI at baseline and after a 4 weeks trial period .