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NCT06576804
Eccentric Cycling Exercise on Mitochondrial Function of Lymphocyte
NA trial testing Eccentric cycling training in Eccentric Exercise Training in 33 participants. Completed in 1 August 2022.
1 January 2022
Quick facts
| Lead sponsor | Chang Gung Memorial Hospital |
|---|---|
| Phase | NA |
| Status | Completed |
| Study type | INTERVENTIONAL |
| Allocation | randomized |
| Design | parallel |
| Masking | single |
| Primary purpose | treatment |
| Enrollment | 33 |
| Start date | 1 January 2021 |
| Primary completion | 1 January 2022 |
| Estimated completion | 1 August 2022 |
| Sites | 1 location across Taiwan |
Drugs / interventions tested
- Eccentric cycling training
- Concentric cycling training
Conditions studied
- Eccentric Exercise Training — all drugs for Eccentric Exercise Training →
Sponsor
Chang Gung Memorial Hospital
Who can join
Adults 20 to 30, male only, with Eccentric Exercise Training. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
Eccentric cycling exercise (ECE) features lower metabolic demand and higher improvement of muscle strength compared to traditional concentric cycling exercise (CCE). Mitochondria can regulate energy metabolism and adaptive immune quality in T lymphocytes. However, the effects of ECE on mitochondrial functions in T-lymphocytes have not yet been established. Method: A total of 33 healthy sedentary males were randomized and divided into ECE (n=11), CCE (n=11), and control groups (n=11). These subjects progressively performed CCE or ECE from 60% to 80% maximal workload on a bicycle ergometer for 40 min/day, 5 days/week for 6 weeks. A graded exercise testing and an isokinetic strength test were conducted to evaluate cardiopulmonary fitness and muscle strength, respectively. Phenotypes and mitochondrial respiratory capacity in T lymphocyte were analyzed using flow cytometry and high-resolution respirometer, respectively.
Publications & conference data
1 peer-reviewed publication reference this trial (live from Europe PMC):
-
Effects of concentric and eccentric exercise regimens on bioenergetic efficiency of lymphocytes in sedentary males.
Peng SC, Lin YT, Hsu CC, Fu TC, et al · · 2024 · cited 2× · PMID 39520384 · DOI 10.1002/ejsc.12221
Verify or expand the search:
- PubMed search for NCT06576804
- Europe PMC full search
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Related trials
Other trials of Eccentric cycling training
Trials testing the same drug.
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- NCT04773444 — Eccentric Cycling Exercise on Hemodynamic and Hemorheologic Properties · NA · unknown
Other recruiting trials for Eccentric Exercise Training
Currently open trials in the same condition.
- NCT07042750 — Eccentric Cycling Exercise During Pulmonary Rehabilitation in Patients With Cardiopulmonary Diseases · NA · recruiting
Other Chang Gung Memorial Hospital trials
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Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT06576804 (US National Library of Medicine, public domain)
- Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by Chang Gung Memorial Hospital
- Last refreshed: 29 August 2024
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT06576804.
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