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NCT06565325
The Immediate Effect of Combined Terminal Knee Extension Exercise With Audible Cues
NA trial testing Exercise + Audible Cues in Muscle Weakness in 30 participants. Completed in 7 March 2025.
7 February 2025
Quick facts
| Lead sponsor | Mahidol University |
|---|---|
| Phase | NA |
| Status | Completed |
| Study type | INTERVENTIONAL |
| Allocation | randomized |
| Design | parallel |
| Masking | single |
| Primary purpose | treatment |
| Enrollment | 30 |
| Start date | 10 February 2024 |
| Primary completion | 7 February 2025 |
| Estimated completion | 7 March 2025 |
| Sites | 1 location across Thailand |
Drugs / interventions tested
- Exercise + Audible Cues
- Exercise
Conditions studied
- Muscle Weakness — all drugs for Muscle Weakness →
Sponsor
Mahidol University
Who can join
Adults 18 to 30, any sex, with Muscle Weakness. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
Typically, patients perform TKE by themselves after exercise prescription. The investigators thought that a lack of attention and preferred speed of patients might not provide the best outcome. Therefore, an increased effectiveness of TKE is interesting for physical therapy implication. Besides, adding sensory input which is audible cues or rhythm during exercise may enhance the efficacy of the exercise by increasing neuromuscular control and function. Therefore, the study aimed to investigate the immediate effects of combined TKE with audible cues on motor unit behavior. The researchers expect that adding rhythm from the metronome will enhance neuromuscular control which may change motor unit behavior of VM muscle. The findings of the study may have helped explain the mechanism behind the acute effects of combined TKE with audible cues on VM function and their potential application in the field of physical therapy. This study aims to investigate the immediate effect of combined TKE with audible cues on motor unit behavior in healthy participants and to investigate reliability of decomposition electromyography procedure during single leg squat.
Publications & conference data
1 peer-reviewed publication reference this trial (live from Europe PMC):
-
Exercise synchronized with audible cues preserves motor unit action potential: a randomized control trial study.
Suntornon P, Kiratisin P, Sinsurin K, Nitkotom S, et al · · 2025 · PMID 41402906 · DOI 10.1186/s13102-025-01490-y
Verify or expand the search:
- PubMed search for NCT06565325
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
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Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT06565325 (US National Library of Medicine, public domain)
- Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by Mahidol University
- Last refreshed: 29 July 2025
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT06565325.
Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing