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RE and Probiotics in MAFLD/NAFLD
This project aims to evaluate the roles of the autonomic nervous system (ANS) and gut microbiota as correlates of clinical improvement in metabolic dysfunction-associated fatty liver disease (MAFLD) and non-alcoholic fatty liver disease (NAFLD) in response to a therapeutic regimen comprising resistance exercise and probiotic supplementation. The primary objective is to investigate the effects of these non-pharmacological interventions on MAFLD/NAFLD and to identify patient phenotypes based on baseline ANS profiles and gut microbiota composition that predict clinical responses.
Details
| Lead sponsor | Nicolaus Copernicus University |
|---|---|
| Phase | NA |
| Status | NOT_YET_RECRUITING |
| Enrolment | 180 |
| Start date | Fri Apr 10 2026 00:00:00 GMT+0000 (Coordinated Universal Time) |
| Completion | Thu Apr 10 2036 00:00:00 GMT+0000 (Coordinated Universal Time) |
Conditions
- NASH
- NAFLD
- MAFLD
Interventions
- physical exercise programme
- probiotics supplementation
- Placebo