NCT06555237 (MEKinRAS) is a Phase 2 clinical trial of Trametinib tablet in Cardiomegaly, sponsored by Medical University of Warsaw.

Who is sponsoring NCT06555237?

NCT06555237 is sponsored by Medical University of Warsaw.

What drugs are being tested in NCT06555237?

Interventions in NCT06555237: Trametinib tablet, Standard therapy.

What condition does NCT06555237 study?

NCT06555237 studies Cardiomegaly, Noonan Syndrome.

Is NCT06555237 still recruiting?

NCT06555237 is currently recruiting now. Last updated 15 August 2024.

Last reviewed 2024-08-15 · How we verify

NCT06555237: MEKinRAS

Name: Drug Landscape Pharmaceutical Database
Creator: Drug Landscape
Published: 2026-01-01
License: https://creativecommons.org/licenses/by/4.0/

MEK Inhibitors for the Treatment of Hypertrophic Cardiomyopathy in Patients With RASopathies

Recruiting now Phase 2 Last updated 15 August 2024

What this trial tests

Phase 2 trial testing Trametinib tablet in Cardiomegaly in 40 participants. Currently enrolling.

Timeline

1 August 2024

Primary endpoint
1 August 2026

1 December 2026

Quick facts

Lead sponsor	Medical University of Warsaw
Phase	Phase 2
Status	Recruiting now
Study type	INTERVENTIONAL
Allocation	randomized
Design	parallel
Masking	none
Primary purpose	treatment
Enrollment	40
Start date	1 August 2024
Primary completion	1 August 2026
Estimated completion	1 December 2026
Sites	1 location across Poland

Drugs / interventions tested

Trametinib tablet — full drug profile →
Standard therapy — full drug profile →

Conditions studied

Cardiomegaly — all drugs for Cardiomegaly →
Noonan Syndrome — all drugs for Noonan Syndrome →

Sponsor

Medical University of Warsaw

Who can join

Adults 1 Day to 18, any sex, with Cardiomegaly or Noonan Syndrome. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

The goal of this study is to evaluate the effectiveness of trametinib treatment in patients with Hyperthropic cardiomyopathy and a genetic mutation in the RAS/MAPK pathway.

Publications & conference data

2 peer-reviewed publications reference this trial (live from Europe PMC):

Trametinib as a targeted treatment in cardiac and lymphatic presentations of Noonan syndrome.
De Brouchoven I, Lorand J, Bofferding L, Sorlin A, et al · · 2025 · cited 3× · PMID 40041314 · DOI 10.3389/fped.2025.1475143
Cardiofaciocutaneous Syndrome Type 4 due to a MAP2K2 Variant: Expanding the Phenotypic Spectrum With Feeding Dysfunction and Neurodevelopmental Involvement.
Świeca A, Rydzanicz M, Ploski R, Szczałuba K. · · 2026 · PMID 41694643 · DOI 10.1002/ccr3.72024

Verify or expand the search:

Other trials of Trametinib tablet

Trials testing the same drug.

NCT07072403 — Trametinib Treatment for Complicated Vascular Anomalies · Phase 1, PHASE2 · active not recruiting
NCT06739395 — Precision Medicine Trial Based on Molecular Matching Therapy for Patients With Standard Treatment Exhaustion · Phase 2 · recruiting
NCT04258046 — Trametinib in the Treatment of Complicated Extracranial Arterial Venous Malformation · Phase 2 · unknown
NCT01647659 — Relative Bioavailibilty for Pediatric Powder for Suspension (PfOS) Formulation · Phase 1 · completed

Other Medical University of Warsaw trials

Trials by the same sponsor.

NCT07515768 — TAVI Without On-Site Cardiac Surgery in Poland: A Randomized Multicenter Trial Protocol · NA · not yet recruiting
NCT07511907 — Routine Intraoperative White Test for Bile Leak Detection in Liver Resection · NA · not yet recruiting
NCT07498660 — PRP Injection Into the Sacroiliac Joint After Ipsilateral THA: Effects on Early Recovery and Function (SIJ-THA Randomize · NA · not yet recruiting
NCT07398898 — Use of Augmented Reality Glasses and Noise-Cancelling Headphones to Reduce Dental Anxiety in Adult Patients · NA · recruiting
NCT07237204 — 15 vs 45 Minute Pringle Maneuver in Liver Cancer Resection: Randomized Noninferiority Trial · NA · not yet recruiting

Verify against primary sources

ClinicalTrials.gov — authoritative US registry record
WHO ICTRP — international registry index
EU Clinical Trials Register
Sponsor press releases (Google)

Data sources for this page

Trial protocol + status: ClinicalTrials.gov NCT06555237 (US National Library of Medicine, public domain)
Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
Sponsor: as reported to ClinicalTrials.gov by Medical University of Warsaw
Last refreshed: 15 August 2024

Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT06555237.

Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing