Who is sponsoring NCT06548828?

NCT06548828 is sponsored by George Washington University.

What drugs are being tested in NCT06548828?

Interventions in NCT06548828: NNS Restriction Intervention, Control Intervention.

What condition does NCT06548828 study?

NCT06548828 studies Gestational Diabetes Mellitus in Pregnancy, Glucose Intolerance During Pregnancy, Non-nutritive Sweeteners Consumption in Pregnancy and/or Lactation.

Is NCT06548828 still recruiting?

NCT06548828 is currently recruiting now. Last updated 18 February 2026.

Last reviewed 2026-02-18 · How we verify

NCT06548828

Name: Drug Landscape Pharmaceutical Database
Creator: Drug Landscape
Published: 2026-01-01
License: https://creativecommons.org/licenses/by/4.0/

Effects of a Non-nutritive Sweetener Reduction Intervention in Pregnancy and Lactation on Maternal and Infant Outcomes

Recruiting now NA Last updated 18 February 2026

What this trial tests

NA trial testing NNS Restriction Intervention in Gestational Diabetes Mellitus in Pregnancy in 324 participants. Currently enrolling.

Timeline

19 August 2024

Primary endpoint
29 February 2028

1 February 2029

Quick facts

Lead sponsor	George Washington University
Phase	NA
Status	Recruiting now
Study type	INTERVENTIONAL
Allocation	randomized
Design	parallel
Masking	single
Primary purpose	treatment
Enrollment	324
Start date	19 August 2024
Primary completion	29 February 2028
Estimated completion	1 February 2029
Sites	1 location across United States

Drugs / interventions tested

NNS Restriction Intervention
Control Intervention — full drug profile →

Conditions studied

Gestational Diabetes Mellitus in Pregnancy — all drugs for Gestational Diabetes Mellitus in Pregnancy →
Glucose Intolerance During Pregnancy — all drugs for Glucose Intolerance During Pregnancy →
Non-nutritive Sweeteners Consumption in Pregnancy and/or Lactation — all drugs for Non-nutritive Sweeteners Consumption in Pregnancy and/or Lactation →

Sponsor

George Washington University

Who can join

Adults 18 to 45, female only, with Gestational Diabetes Mellitus in Pregnancy or Glucose Intolerance During Pregnancy. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

The effects of consuming non-nutritive sweeteners (NNS) during pregnancy and lactation on infant obesity and cardiometabolic disease risk are not well understood. In this project, pregnant women who frequently consume NNS will be randomly assigned to an NNS-restriction intervention (NNS restriction during pregnancy and lactation or during lactation only) or a control group (no NNS restriction) to determine whether NNS consumption during pregnancy and/or lactation affects infant body composition, maternal blood sugar during pregnancy, and the infants' gut microbiome and metabolome. The results of this study have the potential to shape recommendations around NNS consumption during pregnancy and lactation, thereby potentially improving maternal and infant metabolic health and reducing the global burden of obesity and cardiometabolic disease.

Publications & conference data

1 peer-reviewed publication reference this trial (live from Europe PMC):

Microbe on the move: <i>Akkermansia</i> in infectious diseases and emerging roles in gynecological health.
Marroquin SM, Doran KS. · · 2026 · PMID 42060851 · DOI 10.1128/jb.00491-25

Verify or expand the search:

Other recruiting trials for Gestational Diabetes Mellitus in Pregnancy

Currently open trials in the same condition.

NCT05388643 — Early Detection of Gestational Diabetes Mellitus in Pregnancy · NA · recruiting
NCT06957028 — CGM for the Early Detection and Management of Hyperglycemia in Pregnancy · NA · recruiting
NCT06874907 — First Trimester Prediction of Gestational Diabetes Mellitus by Continuous Glucose Monitoring. · recruiting
NCT06802861 — Relationship Between Aspirin Metabolism and Markers of Metabolic Dysfunction Among Pregnant Persons at Risk of Pre-eclam · recruiting
NCT06005987 — Mobile App Logging for Diabetes in Pregnancy · NA · recruiting

Other George Washington University trials

Trials by the same sponsor.

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NCT07079306 — ChatGPT-Supported Text Messaging Program for Smoking Cessation · NA · not yet recruiting

Verify against primary sources

ClinicalTrials.gov — authoritative US registry record
WHO ICTRP — international registry index
EU Clinical Trials Register
Sponsor press releases (Google)

Data sources for this page

Trial protocol + status: ClinicalTrials.gov NCT06548828 (US National Library of Medicine, public domain)
Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
Sponsor: as reported to ClinicalTrials.gov by George Washington University
Last refreshed: 18 February 2026

Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT06548828.

Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing