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NCT06539078: AGAMEMNON
Exercise as a Countermeasure Against the Effects of Ageing on Muscle Mitochondria, Diffusive Oxygen Transport and Muscle Volume
trial testing Maximal exercise test in Aging in 60 participants. Currently enrolling.
1 December 2025
Quick facts
| Lead sponsor | VU University of Amsterdam |
|---|---|
| Status | Recruiting now |
| Study type | OBSERVATIONAL |
| Enrollment | 60 |
| Start date | 25 March 2024 |
| Primary completion | 1 December 2025 |
| Estimated completion | 1 December 2026 |
| Sites | 1 location across Netherlands |
Drugs / interventions tested
- Maximal exercise test
- 3D Ultrasound
- Dynamometry
- Exercise test and occlusions
- Exercise test in MRI
- Muscle biopsy
Conditions studied
- Aging — all drugs for Aging →
Sponsor
VU University of Amsterdam
Who can join
Adults 18 to 65, any sex, with Aging. Healthy volunteers can join.
What's being measured
Primary outcomes are the specific endpoints the trial is designed to prove or disprove.
-
Maximal oxygen uptake (V̇O2max)
Time frame: Baseline (visit 1)
ml/min/kg -
Muscle volume
Time frame: Baseline (visit 1)
cm\^3 -
Muscle strength
Time frame: Baseline (visit 1)
Newton-metre (Nm) -
Muscle power
Time frame: Baseline (visit 1)
Watt (W) -
Muscle diffusing capacity for oxygen (DmO2)
Time frame: Baseline (visit 1) and visit 2-4. In total 4 weeks.
Differences in recovery constant k (min-1) obtained under conditions of high, medium or low O2 availability -
Muscle mitochondrial fragmentation index (A.U.)
Time frame: Visit 6 muscle biopsy (+/- after 4 weeks).
Degree of fragmentation of the mitochondrial pool.
Sponsor's own description
Healthy ageing is associated with the loss of muscle mass and physical function. As a result, older people are limited in their independence. The aging of muscles typically begins around the age of 30. From this age onward, muscle strength, muscle mass, and the maximum oxygen uptake of muscles decrease. The reasons for this are not entirely clear, but it seems to be partly related to how oxygen moves from our blood vessels to the muscles and how muscles burn energy. The precise role of age and physical fitness, as well as whether exercise can counteract the effects of ageing, is still unknown. Therefore, in this study, we aim to investigate the muscle function of both physically active and inactive young and middle-aged individuals. We hypothesise that endurance training can mitigate some of the effects of ageing.
Publications & conference data
No peer-reviewed publications indexed yet for this trial.
Verify or expand the search:
- PubMed search for NCT06539078
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
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Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT06539078 (US National Library of Medicine, public domain)
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by VU University of Amsterdam
- Last refreshed: 2 August 2024
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT06539078.
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