NCT06473207: RIPOST-CA

Neuroprotective Effect of Remote Ischemic Post-conditioning in Out-of-hospital Cardiac Arrest : a Randomized Open Label Controlled Trial

Recruiting now NA Last updated 10 April 2026

What this trial tests

NA trial testing Remote ischemic post conditioning sessions in Out-Of-Hospital Cardiac Arrest in 48 participants. Currently enrolling.

Timeline

11 January 2025

Primary endpoint
1 January 2027

1 April 2027

Quick facts

Lead sponsor	Centre Hospitalier Intercommunal de Toulon La Seyne sur Mer
Phase	NA
Status	Recruiting now
Study type	INTERVENTIONAL
Allocation	randomized
Design	parallel
Masking	none
Primary purpose	treatment
Enrollment	48
Start date	11 January 2025
Primary completion	1 January 2027
Estimated completion	1 April 2027
Sites	1 location across France

Drugs / interventions tested

• Remote ischemic post conditioning sessions
• Sham sessions

Conditions studied

• Out-Of-Hospital Cardiac Arrest — all drugs for Out-Of-Hospital Cardiac Arrest →

Sponsor

Centre Hospitalier Intercommunal de Toulon La Seyne sur Mer

Who can join

18 and older, any sex, with Out-Of-Hospital Cardiac Arrest. Patients with the condition only — healthy volunteers not accepted.

What's being measured

Primary outcomes are the specific endpoints the trial is designed to prove or disprove.

• Neurofilament light chain (NFL) blood level evolution between 6 and 72 hours after cardiac arrest occurrence
  Time frame: 72 hours after out-of-hospital cardiac arrest occurrence
  Blood samples will be performed at 6 and 72 hours after cardiac arrest to monitor NFL level evolution and this evolution will be compared between both arms (RIPOST and sham groups)

Sponsor's own description

Patients admitted to intensive care unit (ICU) following an out-of-hospital cardiac arrest (OHCA) have a high morbidity and mortality rate, primarily due to ischemia-reperfusion (I/R) syndrome leading to anoxic-ischemic brain injury. Despite current recommended advanced life support therapies, no specific treatment or procedure has yet been shown to improve the neurological outcome of such patients.

Remote ischemic post-conditioning (RIPOST) which usually consists of applying brief and repeated cycles of ischemia alternating with reperfusion by inflating and deflating a blood pressure cuff or a pneumatic tourniquet placed around a limb, is a promising strategy to protect organs against I/R injury, including brain. Regarding cardiac arrest, pre-clinical studies have demonstrated an improvement in neurological outcome in animal subjects treated with RIPOST after cardiopulmonary resuscitation.

The aim of our study is to demonstrate the benefit of early RIPOST in OHCA patients in reducing neurological injury and organ failure related to I/R syndrome.

Publications & conference data

1 peer-reviewed publication reference this trial (live from Europe PMC):

1. Remote ischemic conditioning in intensive care: From bench to bedside.
   Benghanem S, Stiel L, Jouan Y, Vedrenne-Cloquet M, et al · · 2026 · PMID 41788501 · DOI 10.1016/j.aicoj.2025.100018