A Randomized Double Blinded Trial of Vitamin A Supplementation in Allogeneic Stem Cell Transplantation.

NCT06450925 Phase 2 RECRUITING

The investigators hypothesize that single oral high dose supplementation with vitamin A will reduce the incidence of moderate-severe chronic graft-versus-host disease (GVHD) compared with placebo.

Details

Lead sponsor	Children's Hospital Medical Center, Cincinnati
Phase	Phase 2
Status	RECRUITING
Enrolment	190
Start date	2025-03-25
Completion	2029-08

Conditions

• Graft Vs Host Disease
• Vitamin A Deficiency
• Vitamin D Deficiency

Interventions

• Vitamin A
• Placebo

Primary outcomes

• Incidence of moderate-severe chronic graft versus host disease (GVHD) — 1 year after transplant
  Incidence of moderate-severe chronic GVHD

Countries

United States