NCT06381193 is a NA clinical trial of Probiotic in Functional Constipation, sponsored by Centros de Investigación de Nutrición y Salud.

Who is sponsoring NCT06381193?

NCT06381193 is sponsored by Centros de Investigación de Nutrición y Salud.

What drugs are being tested in NCT06381193?

Interventions in NCT06381193: Probiotic, Prebiotic, Probiotic + Prebiotic, Placebo.

What condition does NCT06381193 study?

NCT06381193 studies Functional Constipation.

Is NCT06381193 still recruiting?

NCT06381193 is currently completed. Last updated 24 April 2024.

Last reviewed 2024-04-24 · How we verify

NCT06381193

Name: Drug Landscape Pharmaceutical Database
Creator: Drug Landscape
Published: 2026-01-01
License: https://creativecommons.org/licenses/by/4.0/

Study for the Management of Chronic and Functional Constipation Through the Intake of Probiotics and Prebiotics

Completed NA Last updated 24 April 2024

What this trial tests

NA trial testing Probiotic in Functional Constipation in 80 participants. Completed in 10 July 2023.

Timeline

3 March 2023

Primary endpoint
10 July 2023

10 July 2023

Quick facts

Lead sponsor	Centros de Investigación de Nutrición y Salud
Phase	NA
Status	Completed
Study type	INTERVENTIONAL
Allocation	randomized
Design	parallel
Masking	quadruple
Primary purpose	treatment
Enrollment	80
Start date	3 March 2023
Primary completion	10 July 2023
Estimated completion	10 July 2023
Sites	1 location across Spain

Drugs / interventions tested

Probiotic
Prebiotic — full drug profile →
Probiotic + Prebiotic
Placebo

Conditions studied

Functional Constipation — all drugs for Functional Constipation →

Sponsor

Centros de Investigación de Nutrición y Salud

Who can join

Adults 18 to 65, any sex, with Functional Constipation. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

The goal of this clinical trial is to learn if supplementation with prebiotics and/or probiotics can lead to an improvement in symptoms of patients with functional constipation. The main objectives are: * To evaluate the effect of the dietary supplements on the bowel frequency movements in patients with chronic functional constipation, after 8 weeks. * To evaluate the stool consistency after 8 weeks (Bristol scale). * To evaluate the quality of life scale score for patients with Constipation (CVE20 and GSRS scales), after 8 weeks. Participants are randomized into the following groups: * Group A: 20 assigned to probiotic + placebo * Group B: 20 assigned to prebiotic + placebo * Group C: 20 assigned to probiotic + prebiotic * Group D: 20 assigned to the placebo + placebo Participants took 4 units of product per day (2 of each assigned product) for 2 months.

Publications & conference data

2 peer-reviewed publications reference this trial (live from Europe PMC):

Supplementation with probiotics, prebiotics, and synbiotics in patients with chronic functional constipation: a randomized, double-blind, placebo-controlled pilot clinical trial.
Terrén Lora A, Penadés BF, López Oliva S, Arponen S, et al · · 2024 · cited 4× · PMID 39530075 · DOI 10.1093/gastro/goae101
Microbiota-immune crosstalk in the regulation of intestinal motility in constipation.
Pan Z, Zhang T, Ren Z, Zhang H, et al · · 2026 · PMID 42094762 · DOI 10.3389/fmicb.2026.1828926

Verify or expand the search:

Other trials of Probiotic

Trials testing the same drug.

NCT07529457 — Akk09 in Adults With Constipation · NA · not yet recruiting
NCT07507955 — Probiotics for Constipation Relief in Adults · NA · not yet recruiting
NCT07462481 — Probiotic Improve Constipation · NA · recruiting
NCT07511855 — Stress-buffering and Sleep Disturbance-resilient Effects of a Dual Bifidobacterium Longum Combination Under Short-term T · Phase 2 · not yet recruiting
NCT07474064 — Probiotics Combined With Targeted Therapy Plus Immunotherapy in Bladder-Preserving Setting for Patients With MIBC · Phase 2 · not yet recruiting

Other recruiting trials for Functional Constipation

Currently open trials in the same condition.

NCT07148583 — BioAmicus Complete for Functional Gastrointestinal Symptoms in Infants Aged 0 to 24 Months · NA · recruiting
NCT07091084 — A Study of Herbal Supplements in Cancer Survivors With Constipation · NA · recruiting
NCT06534996 — A Single Arm Pilot Study of the Chinese Herbal Medicine Formula (SCD-2101) for the Functional Constipation in the Elderl · NA · recruiting
NCT04918329 — Functional Digestive Disorders Observatory · recruiting
NCT04547816 — Efficacy of Conservative Treatment of Functional Defecatory Disorders in Females With Pelvic Organ Prolapse · Phase 3 · recruiting

Other Centros de Investigación de Nutrición y Salud trials

Trials by the same sponsor.

NCT05389761 — Fibromyalgia Treatment With Enzyme DAO · NA · completed

Verify against primary sources

ClinicalTrials.gov — authoritative US registry record
WHO ICTRP — international registry index
EU Clinical Trials Register
Sponsor press releases (Google)

Data sources for this page

Trial protocol + status: ClinicalTrials.gov NCT06381193 (US National Library of Medicine, public domain)
Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
Sponsor: as reported to ClinicalTrials.gov by Centros de Investigación de Nutrición y Salud
Last refreshed: 24 April 2024

Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT06381193.

Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing