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NCT06377839
Pain After Removal of Mandibular Third Molars With or Without Advanced Platelet-rich Fibrin
EARLY_PHASE1 trial testing Advanced platelet-rich fibrin in the ekstraction socket in Pain Syndrome in 80 participants. Currently enrolling.
17 April 2024
Quick facts
| Lead sponsor | Aalborg University Hospital |
|---|---|
| Phase | EARLY_PHASE1 |
| Status | Recruiting now |
| Study type | INTERVENTIONAL |
| Allocation | randomized |
| Design | parallel |
| Masking | single |
| Primary purpose | treatment |
| Enrollment | 80 |
| Start date | 10 January 2024 |
| Primary completion | 17 April 2024 |
| Estimated completion | 1 December 2025 |
| Sites | 1 location across Denmark |
Drugs / interventions tested
- Advanced platelet-rich fibrin in the ekstraction socket — full drug profile →
Conditions studied
- Pain Syndrome — all drugs for Pain Syndrome →
Sponsor
Aalborg University Hospital
Who can join
18 and older, any sex, with Pain Syndrome. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
Pain is the most common complication following surgical removal of an impacted mandibular third molar. Several risk factors may increase the intensity and duration of pain following removal of mandibular third molars. Acute postoperative pain can transcript into postoperative chronic pain without an explainable reason or a specific risk factor. The use of advanced platelet-rich fibrin in the extraction socket following surgical removal of mandibular third molar have diminished the intensity and duration of acute postoperative pain and facilitated improved wound healing. The objective of the present study is therefore to identified specific risk factors and predictors for developing postoperative chronic pain following surgical removal of mandibular third molars with or without advanced platelet-rich fibrin applied in the extraction socket using epigenetic modulation.
Publications & conference data
1 peer-reviewed publication reference this trial (live from Europe PMC):
-
Long-term Assessment of Oral Health-Related Quality of Life Following Surgical Removal of Mandibular Third Molar with Advanced Platelet-rich Fibrin: a Single-blinded Randomized Controlled Trial
Starch-Jensen T, Giordano R, Alsadi D, Bruun N, et al · · 2026
Verify or expand the search:
- PubMed search for NCT06377839
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
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Other Aalborg University Hospital trials
Trials by the same sponsor.
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Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT06377839 (US National Library of Medicine, public domain)
- Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by Aalborg University Hospital
- Last refreshed: 22 April 2024
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT06377839.
Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing