Last reviewed · How we verify
NCT06376461: GUTPHOS
Prospective, Multicentre Study to Validate the GastroIntestinal Dysfunction Score (GIDS) and Describe Prevalence, Outcomes, and Management of Phosphate Disorders in Intensive Care Patients
trial testing Data collection in Gastrointestinal Dysfunction in 92 participants. Completed in 26 June 2025.
31 March 2025
Quick facts
| Lead sponsor | University Hospitals of North Midlands NHS Trust |
|---|---|
| Status | Completed |
| Study type | OBSERVATIONAL |
| Enrollment | 92 |
| Start date | 26 July 2024 |
| Primary completion | 31 March 2025 |
| Estimated completion | 26 June 2025 |
| Sites | 1 location across United Kingdom |
Drugs / interventions tested
- Data collection — full drug profile →
Conditions studied
- Gastrointestinal Dysfunction — all drugs for Gastrointestinal Dysfunction →
Sponsor
University Hospitals of North Midlands NHS Trust
Who can join
18 and older, any sex, with Gastrointestinal Dysfunction. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
Part A Multiple organ dysfunction syndrome is one of the main problems in critically ill patients. Several organ dysfunctions are routinely and systematically monitored in patients admitted to intensive care units. Gastrointestinal dysfunction is currently not included in multiple organ dysfunction scores and lacks a standardised approach. At the same time, investigators earlier studies have shown that gastrointestinal dysfunction plays an essential role in the course of illness in intensive care patients. A tool for measuring dysfunction is needed to enable future studies on interventions to improve gastrointestinal function. The GIDS (GastroIntestinal Dysfunction Score) combines different clinical signs and symptoms commonly observed and documented in patients in the ICU into a scoring system, allowing distinguishing between different grades of severity of dysfunction. The investigators will only use observations documented during the patient's stay in the intensive care unit without additional measurements and calculate gastrointestinal (GIDS) and other organ dysfunction scores. Part B Phosphate is an electrolyte commonly measured and often corrected, while the indications and clear guidance for correction are insufficiently studied. The results of this study will assist in specifying indications for the correction of phosphate levels better and refine the management strategies in the future. Only phosphate levels measured as part of routine care will be documented, no additional samples for study purposes will be taken, and the study will not influence the treatment of phosphate disorders.
Publications & conference data
1 peer-reviewed publication reference this trial (live from Europe PMC):
-
Hypophosphataemia in Critical Illness: A Narrative Review.
Ramanan M, Tabah A, Affleck J, Edwards F, et al · · 2024 · cited 3× · PMID 39685625 · DOI 10.3390/jcm13237165
Verify or expand the search:
- PubMed search for NCT06376461
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
Related trials
Other trials of Data collection
Trials testing the same drug.
- NCT07010562 — A Multi-site, Pre-clinical, Prospective Data Collection Study in Patients Undergoing a Right Heart Catheterization · not yet recruiting
- NCT07418359 — Comparison of Patient's Physical Activity Levels According to the Physical Activity Level of Their General Practitioner · recruiting
- NCT07197398 — Preoperative Data and the Spinal Spread of Local Anesthetic in Cesarean Section · recruiting
- NCT06998797 — Efficacy of Subcutaneous Infliximab in Acute Severe Ulcerative Colitis: a Multicenter Retrospective Study · not yet recruiting
- NCT07529730 — Outcomes of Surgical Treatment in Patients With Infective Endocarditis · completed
Other recruiting trials for Gastrointestinal Dysfunction
Currently open trials in the same condition.
- NCT07252102 — Effect of HFNC on Incidence of Hypoxia During Sedated Gastrointestinal Endoscopy in Critical Patients · NA · recruiting
- NCT06510348 — Achieving nuTritional Target in criticAlly Ill patieNts With iMpairEd gastroiNtesTinal Dysfunction · NA · recruiting
- NCT06740903 — Evaluating Perioperative Outcomes: Dexmedetomidine vs Lignocaine in Laparoscopic Chlolecystectomy · Phase 2, PHASE3 · recruiting
- NCT06386471 — Personalized GI Motility Responses to Diet · NA · recruiting
- NCT05344417 — Low Pressure Pneumoperitoneum and Postoperative Ileus · NA · recruiting
Other University Hospitals of North Midlands NHS Trust trials
Trials by the same sponsor.
- NCT07006662 — Anatomical Landmarks for Chest Wall Perforators Used for Partial Breast Reconstruction · not yet recruiting
- NCT06002009 — SupraScapular Cuff Study: Assessing the Effects of Size and Type of Rotator Cuff Tear on Suprascapular Nerve Function · recruiting
- NCT06050720 — Sleep Apnoea Breathing Record Exploratory Study (SABRES) · NA · active not recruiting
- NCT06038669 — User Evaluation of a Home-collection Kit for People With Diabetes · active not recruiting
- NCT06170879 — What is the Experience of the Professional Nurse Advocates (PNAs) Application of the A-EQUIP Model Into Practice · unknown
Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT06376461 (US National Library of Medicine, public domain)
- Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by University Hospitals of North Midlands NHS Trust
- Last refreshed: 3 July 2025
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT06376461.
Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing