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NCT06372444: PET-AKI
Mechanisms of Acute Kidney Injury in Severe Infections
trial testing Positron emission tomography (PET) in Sepsis in 15 participants. Currently enrolling.
3 April 2026
Quick facts
| Lead sponsor | Uppsala University Hospital |
|---|---|
| Status | Recruiting now |
| Study type | OBSERVATIONAL |
| Enrollment | 15 |
| Start date | 1 May 2024 |
| Primary completion | 3 April 2026 |
| Estimated completion | 30 June 2026 |
| Sites | 1 location across Sweden |
Drugs / interventions tested
- Positron emission tomography (PET) — full drug profile →
Conditions studied
- Sepsis — all drugs for Sepsis →
- AKI - Acute Kidney Injury — all drugs for AKI - Acute Kidney Injury →
- Positron Emission Tomography (PET) — all drugs for Positron Emission Tomography (PET) →
Sponsor
Uppsala University Hospital
Who can join
30 and older, any sex, with Sepsis or AKI - Acute Kidney Injury. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
Renal perfusion and neutrophil-mediated inflammation will be assessed in the kidney in sepsis patients with acute kidney injury using positron emission tomography. For marked water will be used for renal perfusion and a newly developed PET tracer molecule (11C-GW457427) with specific binding to neutrophil elastase which provides a measure of the amount of infiltrating neutrophils in the renal parenchyma for inflammation. The study is performed in a PET-CT camera where anatomical imaging takes place at the same time as the PET examinations.
Publications & conference data
1 peer-reviewed publication reference this trial (live from Europe PMC):
-
In Vivo Imaging of the Innate Immune System in the Pancreas in New-Onset and Long-Standing Type 1 Diabetes.
Anvari E, Zhang H, Hill H, Missima NG, et al · · 2026 · PMID 41872999 · DOI 10.1111/dom.70672
Verify or expand the search:
- PubMed search for NCT06372444
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
Related trials
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Trials testing the same drug.
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- NCT07218224 — Expanded Access:18F-Fluorocholine for the Detection of Parathyroid Adenomas · available
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Currently open trials in the same condition.
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Other Uppsala University Hospital trials
Trials by the same sponsor.
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Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT06372444 (US National Library of Medicine, public domain)
- Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by Uppsala University Hospital
- Last refreshed: 6 December 2024
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT06372444.
Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing