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NCT06372301: DobAttrAS
Dobutamine Stress Echocardiography in LF/LG Aortic Stenosis and Wild-type Transthyretin Amyloid Cardiomyopathy
NA trial testing Dobutamine stress echocardiography in Transthyretin Amyloid Cardiomyopathy in 24 participants. Currently enrolling.
1 November 2025
Quick facts
| Lead sponsor | Steen Hvitfeldt Poulsen |
|---|---|
| Phase | NA |
| Status | Recruiting now |
| Study type | INTERVENTIONAL |
| Allocation | na |
| Design | single group |
| Masking | none |
| Primary purpose | diagnostic |
| Enrollment | 24 |
| Start date | 2 April 2024 |
| Primary completion | 1 November 2025 |
| Estimated completion | 1 April 2026 |
| Sites | 1 location across Denmark |
Drugs / interventions tested
- Dobutamine stress echocardiography
Conditions studied
- Transthyretin Amyloid Cardiomyopathy — all drugs for Transthyretin Amyloid Cardiomyopathy →
- Aortic Stenosis — all drugs for Aortic Stenosis →
Sponsor
Steen Hvitfeldt Poulsen — full company profile →
Who can join
65 and older, any sex, with Transthyretin Amyloid Cardiomyopathy or Aortic Stenosis. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
The goal of this prospective clinical study is improve the diagnosis of Low-flow low-gradient aortic stenosis (LF/LG AS), in patients with co-existing wild-type transthyretin cardiac amyloidosis (ATTRwt). The main question it aims to answer is whether the classic dobutamine-stress echocardiography can be used to determine AS severity in patients with ATTRwt and LF/LG AS This question will be tried to answer by comparing dobutamine stress echocardiography, with the invasively measured aortic valve area (which is considered as the gold standard). In addition we aim to assess the degree of myocardial fibrosis and amyloid infiltration, assessed by light microscopy and cardiac magnetic resonance (CMRI) and evaluation of myocyte mitochondrial function by high resolution respirometry and their relation to AS severity and hemodynamic response to dobutamine.
Publications & conference data
No peer-reviewed publications indexed yet for this trial.
Verify or expand the search:
- PubMed search for NCT06372301
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Related trials
Other trials of Dobutamine stress echocardiography
Trials testing the same drug.
- NCT02727504 — Low Flow Low Gradient Aortic Stenosis Relevance of the (re)Search for a Contractile Reserve · completed
Other recruiting trials for Transthyretin Amyloid Cardiomyopathy
Currently open trials in the same condition.
- NCT07448623 — A Research Study to Look at the Distribution and Effects of Coramitug on Amyloid Deposits in Heart Tissue Using PET/CT I · Phase 1 · recruiting
- NCT07298044 — A Study to Learn More About the Change in the Blood Levels of Transthyretin When Participants With Transthyretin Amyloid · Phase 4 · recruiting
- NCT06101108 — Early Diagnosis of Age-Linked CArdiac TransThyRetin Amyloidosis by Selective Screening in Spinal Stenosis Surgery · recruiting
- NCT06539169 — FLOWER: Following Longitudinal Outcomes With Epidemiology for Rare Diseases · recruiting
- NCT06183931 — Study of ALXN2220 Versus Placebo in Adults With ATTR-CM · Phase 3 · active not recruiting
Other Steen Hvitfeldt Poulsen trials
Trials by the same sponsor.
- NCT05701397 — Prevalence of Cardiac Amyloidosis in Patients Undergoing Surgery for Lumbar Spinal Stenosis. · NA · unknown
- NCT05701410 — Prevalence of Cardiac Amyloidosis Among Patients With a History of Lumbar Spinal Stenosis. · NA · unknown
- NCT05699044 — Screening of ATTRwt in Patient With Advanced AV-Block Undergoing Pacemaker Implantation · unknown
- NCT05633563 — The Effect of Trimetazidine on Mitochondrial Function, Myocardial Performance, and Invasive Hemodynamics in Patients Dia · Phase 4 · completed
- NCT04276220 — Prevalence of wtATTR-CM After Carpal Tunnel Release Surgery · NA · completed
Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT06372301 (US National Library of Medicine, public domain)
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by Steen Hvitfeldt Poulsen
- Last refreshed: 18 April 2024
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT06372301.
Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing