NCT06370104: TREASURE

Treating Suicidality Remotely

Recruiting now NA Last updated 20 May 2024

What this trial tests

NA trial testing Brief Cognitive Behavioral Therapy for Suicide Prevention in Suicide Attempt in 364 participants. Currently enrolling.

Timeline

7 May 2024

Primary endpoint
25 April 2028

25 April 2028

Quick facts

Lead sponsor	113 Suicide Prevention
Phase	NA
Status	Recruiting now
Study type	INTERVENTIONAL
Allocation	randomized
Design	parallel
Masking	single
Primary purpose	prevention
Enrollment	364
Start date	7 May 2024
Primary completion	25 April 2028
Estimated completion	25 April 2028
Sites	1 location across Netherlands

Drugs / interventions tested

• Brief Cognitive Behavioral Therapy for Suicide Prevention
• Living under control

Conditions studied

• Suicide Attempt — all drugs for Suicide Attempt →

Sponsor

113 Suicide Prevention

Who can join

16 and older, any sex, with Suicide Attempt. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

Background: Practical and psychological barriers make it difficult for people with Suicidal Thoughts and Behaviors (STBs) to get professional help. Online interventions have the potential to overcome many of these barriers, but the online interventions to date have produced small or short-lived effects and have only been found to reduce suicidal thoughts, not behaviors. This is a crucial limitation, since previous studies have shown that interventions that reduce suicidal thoughts often do not prevent suicide attempts, and vice versa.

Methods: A fully remote randomized controlled trial will be conducted in which 364 participants of 16 years and older will be recruited through the website of a suicide prevention helpline in the Netherlands and randomized with an allocation ratio of 1:1 to either Brief Cognitive Behavioral Therapy for Suicide Prevention (BCBT-SP) or a semi-guided online self-help course that has previously been found superior to waitlist in reducing suicidal thoughts. The primary outcome of the study is the number of suicide attempts, measured with the Columbia Suicide Severity Rating Scale. Secondary outcomes are self-reported suicidal ideation, healthcare utilization, treatment satisfaction, adverse effects, and quality of life. All outcomes will be assessed at baseline, immediately after the treatment and at 18 months follow-up.

Discussion: If remote BCBT-SP proves effective, the findings of this study will add to the evidence base of BCBT-SP as one of very few psychological interventions with replicated effectiveness in preventing suicide attempts and provide the first evidence to date that remote interventions cannot only reduce suicidal thoughts, but also prevent suicidal behavior.

Publications & conference data

1 peer-reviewed publication reference this trial (live from Europe PMC):

1. Treating suicidality remotely (TREASURE): study protocol for a remote randomized controlled trial comparing personalized cognitive behavioral therapy for suicide prevention with a guided self-help course in adolescents and adults.
   Janssen W, Mérelle S, Gilissen R, Bockting C. · · 2026 · PMID 42015291 · DOI 10.1186/s13063-026-09725-0