Who is sponsoring NCT06369142?

NCT06369142 is sponsored by Deutsches Herzzentrum Muenchen.

What drugs are being tested in NCT06369142?

Interventions in NCT06369142: Intravascular lithotripsy (IVL), Standard non-IVL methods.

What condition does NCT06369142 study?

NCT06369142 studies Coronary Artery Disease.

Is NCT06369142 still recruiting?

NCT06369142 is currently recruiting now. Last updated 6 January 2026.

Last reviewed 2026-01-06 · How we verify

NCT06369142: ISAR-WAVE

Name: Drug Landscape Pharmaceutical Database
Creator: Drug Landscape
Published: 2026-01-01
License: https://creativecommons.org/licenses/by/4.0/

Intracoronary Stenting and Additional Results Achieved by ShockWAVE Coronary Lithotripsy

Recruiting now NA Last updated 6 January 2026

What this trial tests

NA trial testing Intravascular lithotripsy (IVL) in Coronary Artery Disease in 666 participants. Currently enrolling.

Timeline

1 July 2024

Primary endpoint
30 April 2027

31 July 2027

Quick facts

Lead sponsor	Deutsches Herzzentrum Muenchen
Phase	NA
Status	Recruiting now
Study type	INTERVENTIONAL
Allocation	randomized
Design	parallel
Masking	double
Primary purpose	treatment
Enrollment	666
Start date	1 July 2024
Primary completion	30 April 2027
Estimated completion	31 July 2027
Sites	22 locations across Germany

Drugs / interventions tested

Intravascular lithotripsy (IVL)
Standard non-IVL methods

Conditions studied

Coronary Artery Disease — all drugs for Coronary Artery Disease →

Sponsor

Deutsches Herzzentrum Muenchen — full company profile →

Who can join

18 and older, any sex, with Coronary Artery Disease. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

The clinical trial is intended to evaluate the efficacy, safety and economic benefit of coronary lithotripsy compared to other additional procedures (cutting or super high pressure balloon angioplasty, ablative procedures) in lesion preparation and interventional treatment of severely calcified coronary stenoses.

Publications & conference data

2 peer-reviewed publications reference this trial (live from Europe PMC):

Intracoronary stenting and additional results achieved by shockWAVE coronary lithotripsy: design and rationale of ISAR-WAVE trial.
Cassese S, Simonetti F, Covarrubias HAA, Janisch M, et al · · 2025 · cited 3× · PMID 39710352 · DOI 10.1016/j.ahj.2024.12.008
Percutaneous Coronary Interventions for Calcified Lesions: A Systematic Review with Meta-analyses of Randomised Trials.
Kristensen AT, Faltermeier P, Kamp CB, Jakobsen JC, et al · · 2025 · cited 1× · PMID 41346358 · DOI 10.15420/icr.2025.10

Verify or expand the search:

Other trials of Intravascular lithotripsy (IVL)

Trials testing the same drug.

NCT05072730 — ComparIson of Strategies to PrepAre SeveRely CALCified Coronary Lesions 2 · NA · unknown

Other recruiting trials for Coronary Artery Disease

Currently open trials in the same condition.

NCT07399002 — LONG NAGOMI™ PMCF STUDY · recruiting
NCT07420582 — Antegrade Autologous Blood Reinfusion After CPB · recruiting
NCT07493603 — A Study on Yiyang Huoluo Decoction in the Treatment of Coronary Heart Disease · Phase 1, PHASE2 · recruiting
NCT06535568 — Single vs. Dual Antiplatelet Therapy in Elderly or HBR Patients Undergoing Percutaneous Intervention With DCB (PICCOLETO · NA · recruiting
NCT07286578 — A Prospective, Multicenter, Randomized Controlled Trial to Investigate the Value of Coronary CT Angiography in the Under · NA · recruiting

Other Deutsches Herzzentrum Muenchen trials

Trials by the same sponsor.

NCT07344480 — Retrospective Natural History Study of RASopathy-associated Cardiomyopathy (RAS-CM) · recruiting
NCT06753227 — Invasive Versus Echocardiography-derived Transvalvular Gradients After TAVI Usign Balloon-expandable Transcatheter Heart · enrolling by invitation
NCT06814574 — Pacemaker Implantation Following Transcatheter Tricuspid Valve Replacement · recruiting
NCT06060912 — LAmbre Versus AMPLATZER Amulet Left AtrIal Appendage Occluder for StRoke ProphylaxIs · NA · recruiting
NCT05072730 — ComparIson of Strategies to PrepAre SeveRely CALCified Coronary Lesions 2 · NA · unknown

Verify against primary sources

ClinicalTrials.gov — authoritative US registry record
WHO ICTRP — international registry index
EU Clinical Trials Register
Sponsor press releases (Google)

Data sources for this page

Trial protocol + status: ClinicalTrials.gov NCT06369142 (US National Library of Medicine, public domain)
Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
Sponsor: as reported to ClinicalTrials.gov by Deutsches Herzzentrum Muenchen
Last refreshed: 6 January 2026

Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT06369142.

Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing