NCT06367296: RETOPO

Resistance Exercise Training in the Older Population With Obesity

Recruiting now NA Last updated 27 January 2025

What this trial tests

NA trial testing Prolonged resistance exercise training in Aging in 32 participants. Currently enrolling.

Timeline

1 July 2024

Primary endpoint
28 January 2025

1 June 2025

Quick facts

Lead sponsor	Universidad de La Frontera
Phase	NA
Status	Recruiting now
Study type	INTERVENTIONAL
Allocation	non randomized
Design	parallel
Masking	single
Primary purpose	screening
Enrollment	32
Start date	1 July 2024
Primary completion	28 January 2025
Estimated completion	1 June 2025
Sites	2 locations across Chile

Drugs / interventions tested

• Prolonged resistance exercise training

Conditions studied

• Aging — all drugs for Aging →
• Obesity — all drugs for Obesity →

Sponsor

Universidad de La Frontera — full company profile →

Who can join

Adults 60 to 79, female only, with Aging or Obesity. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

Background:

Aging leads to an alteration in the immune response, characterized by a chronic inflammatory state, and a progressive decrease in muscle quantity and quality, a situation that increases in women and in the presence of obesity. With respect to muscle quality, intramuscular infiltration of adipose tissue has been considered a relevant parameter, involved in the relationship between aging-obesity-inflammation. As a therapeutic strategy, physical training with resistance exercises (or also known as strength training) has been shown to be effective in increasing skeletal muscle mass in this age group. However, its role on muscle quality in normal-weight versus obese older women has not been fully addressed.

Hypothesis:

A 12-week resistance exercise training program is effective in improving muscle quality, immune response and physical performance in normal weight and obese older women. In addition to the above, the investigators hypothesize that women with obesity will present greater baseline alterations, so the percentage of change will be higher compared to older women with normal weight after the training program.

Goals:

The primary aim of this study is to evaluate the effects of a 12-week resistance exercise training on muscle quality (infiltration of intramuscular adipose tissue), immune response and physical performance in older women between 60 and 79 years of age with obesity compared to older women with normal weight of the same age range.

Methodology:

The present clinical trial will consider 2 groups of older women between 60 and 79 years old: normal weight (BMI=18.5 to 24.9 kg/m 2 and % fat \<25.9) and obese (BMI =30 to 39.9 Kg/m 2 and fat % \>32). Participants will perform 12 weeks of training with resistance exercises 3 times a week. Before and after training, intramuscular infiltration of adipose tissue (echogenicity) will be measured by ultrasound, followed by aspects of muscle architecture (muscle thickness, penile angle and fascicle length) and functional parameters of muscle quality (maximum strength determined by 1 repetition maximum-1RM, maximum voluntary isometric strength of knee extensors through a lower limb force and power transducer). Finally, fasting blood samples will be obtained (immune response) and physical performance, body composition, physical activity level, and quality of life will be evaluated.

Publications & conference data

1 peer-reviewed publication reference this trial (live from Europe PMC):

1. Effects of 12 weeks resistance training on muscle quality and physical performance in normal-weight and obese older women.
   Vidal-Seguel N, Sepúlveda-Lara A, Carranza-Leiva J, Márquez C, et al · · 2026 · PMID 42146007 · DOI 10.3389/fphys.2026.1794580