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NCT06363591: WoW
WoW - Single- vs Two-staged Excisions of Thin Melanoma
NA trial testing Surgery in Melanoma in 2,486 participants. Currently enrolling.
31 December 2034
Quick facts
| Lead sponsor | Vastra Gotaland Region |
|---|---|
| Phase | NA |
| Status | Recruiting now |
| Study type | INTERVENTIONAL |
| Allocation | randomized |
| Design | parallel |
| Masking | none |
| Primary purpose | treatment |
| Enrollment | 2,486 |
| Start date | 22 January 2025 |
| Primary completion | 31 December 2034 |
| Estimated completion | 31 December 2039 |
| Sites | 1 location across Sweden |
Drugs / interventions tested
- Surgery
- No Surgery
Conditions studied
- Melanoma — all drugs for Melanoma →
Sponsor
Vastra Gotaland Region — full company profile →
Who can join
18 and older, any sex, with Melanoma. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
The overall aim of this national, multicenter, prospective, randomized, and controlled study is to enhance the management of patients with thin melanoma (≤1 mm Breslow thickness). The investigators hypothesize that wide local excisions (WLEs) following complete excision of thin melanoma do not affect the risk of recurrence, defined as the occurrence of local, regional, distant disease, or melanoma-specific death during a 5- to 10-year follow-up period.
Publications & conference data
3 peer-reviewed publications reference this trial (live from Europe PMC):
-
Wise or wide (WoW) study protocol: a national, multicentre, prospective, randomised and controlled, parallel group, non-inferiority study to compare single-staged versus two-staged excisions of thin invasive (≤1.0 mm) melanoma.
Wennberg E, Claeson M, Olofsson Bagge R, Polesie S, et al · · 2025 · cited 3× · PMID 40180392 · DOI 10.1136/bmjopen-2024-094544 -
Narrow Excision Margins for Diverse Histological Subtypes of Cutaneous Melanoma in Children and Adults: A Systematic Review.
Balado-Simó P, Mansilla-Polo M, Morgado-Carrasco D. · · 2026 · PMID 41735604 · DOI 10.1007/s13555-026-01684-3 -
The Frequency of Microsatellite Metastases, Satellite Metastases, and Residual Tumor in Thin Melanomas: A Retrospective Cohort Study.
Wennberg E, Bittar R, Svensson H, Paoli J. · · 2025 · PMID 40401854 · DOI 10.5826/dpc.1502a5157
Verify or expand the search:
- PubMed search for NCT06363591
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
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Other Vastra Gotaland Region trials
Trials by the same sponsor.
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Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT06363591 (US National Library of Medicine, public domain)
- Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by Vastra Gotaland Region
- Last refreshed: 5 March 2025
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT06363591.
Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing