NCT06359990 (BrotherlyACT) is a NA clinical trial of BrotherlyACT in Violence in Adolescence, sponsored by Rush University Medical Center.

Who is sponsoring NCT06359990?

NCT06359990 is sponsored by Rush University Medical Center.

What drugs are being tested in NCT06359990?

Interventions in NCT06359990: BrotherlyACT, BrotherlyACT Waitlist Control Group (WCG).

What condition does NCT06359990 study?

NCT06359990 studies Violence in Adolescence, Substance Use, Avoidance of Healthcare.

Is NCT06359990 still recruiting?

NCT06359990 is currently active, enrolled. Last updated 23 April 2025.

Last reviewed 2025-04-23 · How we verify

NCT06359990: BrotherlyACT

Name: Drug Landscape Pharmaceutical Database
Creator: Drug Landscape
Published: 2026-01-01
License: https://creativecommons.org/licenses/by/4.0/

BrotherlyACT: A Tech-Enhanced Violence and Substance Use Intervention for Black Boys and Young Men

Active, enrolled NA Last updated 23 April 2025

What this trial tests

NA trial testing BrotherlyACT in Violence in Adolescence in 300 participants. Participants enrolled and being followed up; not accepting new ones.

Timeline

15 February 2024

Primary endpoint
15 February 2027

15 February 2027

Quick facts

Lead sponsor	Rush University Medical Center
Phase	NA
Status	Active, enrolled
Study type	INTERVENTIONAL
Allocation	randomized
Design	parallel
Masking	triple
Primary purpose	prevention
Enrollment	300
Start date	15 February 2024
Primary completion	15 February 2027
Estimated completion	15 February 2027
Sites	1 location across United States

Drugs / interventions tested

BrotherlyACT
BrotherlyACT Waitlist Control Group (WCG)

Conditions studied

Violence in Adolescence — all drugs for Violence in Adolescence →
Substance Use — all drugs for Substance Use →
Avoidance of Healthcare — all drugs for Avoidance of Healthcare →

Sponsor

Rush University Medical Center

Who can join

Adults 15 to 24, male only, with Violence in Adolescence or Substance Use. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

This study will adapt and test a culturally tailored, multi-component, and trauma-focused digital intervention to reduce the risk and effects of youth violence and substance use and bridge service access gaps for young Black males (YBM) in pediatric emergency and community-based low-resource settings.

Publications & conference data

3 peer-reviewed publications reference this trial (live from Europe PMC):

Evaluating an App-Based Intervention for Preventing Firearm Violence and Substance Use in Young Black Boys and Men: Usability Evaluation Study.
Emezue C, Dan-Irabor D, Froilan A, Dunlap A, et al · · 2024 · cited 3× · PMID 39589765 · DOI 10.2196/60918
Evaluating a Digital Intervention to Reduce Aggression and Pro-Firearm Violence Attitudes Among Young Black Males: Pretest-Posttest Feasibility Study.
Emezue C, Bishop-Royse J, Froilan A, Wilkes T, et al · · 2025 · cited 1× · PMID 40854206 · DOI 10.2196/70048
Aggression and attitudes toward firearm violence among high-risk youth: the moderating influence of psychological distress.
Emezue C. · · 2026 · PMID 41604035 · DOI 10.1186/s40352-026-00398-0

Verify or expand the search:

Other recruiting trials for Violence in Adolescence

Currently open trials in the same condition.

NCT06309134 — The Healthy Families Bright Futures Program · NA · recruiting
NCT05768217 — Community Resiliency Collective Efficacy Intervention · NA · recruiting
NCT05743478 — Forging Hopeful Futures to Reduce Youth Violence · NA · active not recruiting
NCT04850274 — Using Re-inforcement Learning to Automatically Adapt a Remote Therapy Intervention (RTI) for Reducing Adolescent Violenc · NA · active not recruiting

Other Rush University Medical Center trials

Trials by the same sponsor.

NCT07278076 — Clinical Decision-Making During FEES: The Impact of Residue Amount and Location · NA · not yet recruiting
NCT07088120 — PRECISION-CPR: PRecision-Controlled Ventilation in CPR · NA · not yet recruiting
NCT06894719 — Oral Tranexamic Acid After Total Knee Arthroplasty · Phase 4 · not yet recruiting
NCT06229392 — A Study to Evaluate the Intratumoral Influenza Vaccine Administration in Patients With Breast Cancer · Phase 1 · withdrawn
NCT07452406 — Protocolized Weaning of High-Flow Nasal Cannula in Adult Patients · NA · not yet recruiting

Verify against primary sources

ClinicalTrials.gov — authoritative US registry record
WHO ICTRP — international registry index
EU Clinical Trials Register
Sponsor press releases (Google)

Data sources for this page

Trial protocol + status: ClinicalTrials.gov NCT06359990 (US National Library of Medicine, public domain)
Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
Sponsor: as reported to ClinicalTrials.gov by Rush University Medical Center
Last refreshed: 23 April 2025

Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT06359990.

Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing