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NCT06358898
Digital Mood-enhanced CBT-I to Improve Depressive Symptoms in Adolescents
NA trial testing Standard dCBT-I in Insomnia in 343 participants. Currently enrolling.
31 May 2026
Quick facts
| Lead sponsor | Chinese University of Hong Kong |
|---|---|
| Phase | NA |
| Status | Recruiting now |
| Study type | INTERVENTIONAL |
| Allocation | randomized |
| Design | parallel |
| Masking | double |
| Primary purpose | treatment |
| Enrollment | 343 |
| Start date | 20 April 2024 |
| Primary completion | 31 May 2026 |
| Estimated completion | 31 December 2026 |
| Sites | 1 location across Hong Kong |
Drugs / interventions tested
- Standard dCBT-I
- Modified Mood enhanced CBT-I (M-dCBT-I)
Conditions studied
- Insomnia — all drugs for Insomnia →
- Depression — all drugs for Depression →
- Adolescent — all drugs for Adolescent →
Sponsor
Chinese University of Hong Kong
Who can join
Adults 12 to 18, any sex, with Insomnia or Depression. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
Emerging encouraging evidence showed that sleep focused treatment can simultaneously improve sleep and depression in adult with comorbid conditions. Although these favorable changes in depressed adults is encouraging, little is known in the potential efficacy of CBT-I in altering depression trajectory in adolescent population. This current study aims to compare the effect of digitally delivered, mood enhanced cognitive behavioral therapy for insomnia (M-dCBT-I) and standard digital cognitive behavioral therapy for insomnia (dCBT-I) in improving depressive symptoms in adolescents, and to examine the potential sustained treatment effect in mood outcomes following M-dCBT-I or dCBT-I treatment.
Publications & conference data
No peer-reviewed publications indexed yet for this trial.
Verify or expand the search:
- PubMed search for NCT06358898
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
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Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT06358898 (US National Library of Medicine, public domain)
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by Chinese University of Hong Kong
- Last refreshed: 10 July 2025
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