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NCT06350617
Personalized rTMS Protocol Based on Functional Reserve to Enhance Ambulatory Function in PD Patients
NA trial testing High-Frequency, ipsilateral M1 in Parkinson's Disease and Parkinsonism in 60 participants. Currently enrolling.
30 September 2025
Quick facts
| Lead sponsor | Samsung Medical Center |
|---|---|
| Phase | NA |
| Status | Recruiting now |
| Study type | INTERVENTIONAL |
| Allocation | randomized |
| Design | parallel |
| Masking | triple |
| Primary purpose | treatment |
| Enrollment | 60 |
| Start date | 20 February 2024 |
| Primary completion | 30 September 2025 |
| Estimated completion | 30 September 2025 |
| Sites | 1 location across South Korea |
Drugs / interventions tested
- High-Frequency, ipsilateral M1
- High-Frequency, bilateral M1
- High-Frequency, Lt. DLPFC
- High-Frequency, bilateral M1
Conditions studied
- Parkinson's Disease and Parkinsonism — all drugs for Parkinson's Disease and Parkinsonism →
Sponsor
Samsung Medical Center
Who can join
50 and older, any sex, with Parkinson's Disease and Parkinsonism. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
The objective of this study was to determine the effects of protocols of repetitive transcranial magnetic stimulation (rTMS) therapy based on the functional reserve of each patient with Parkinson's disease, compared to conventional high-frequency rTMS therapy on bilateral primary motor cortex (M1). Investigators hypothesized that the functional reserve of each patient with Parkinson's disease will be different, and therefore an appropriate simulating target for rTMS therapy is needed. In addition, this approach could be more effective compared to conventional protocols applied to patient with Parkinson's disease regardless of their severity, predicted mechanism of motor function recovery, or functional reserves.
Publications & conference data
1 peer-reviewed publication reference this trial (live from Europe PMC):
-
Efficacy of personalized repetitive transcranial magnetic stimulation based on functional reserve to enhance ambulatory function in patients with Parkinson's disease: study protocol for a randomized controlled trial.
Yun SJ, Lee HS, Kim DH, Im S, et al · · 2024 · cited 3× · PMID 39152467 · DOI 10.1186/s13063-024-08385-2
Verify or expand the search:
- PubMed search for NCT06350617
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
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Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT06350617 (US National Library of Medicine, public domain)
- Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by Samsung Medical Center
- Last refreshed: 5 April 2024
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT06350617.
Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing