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NCT06344611

Incidence & Predictive Factors of Recompensation in Children With Decompensated Cirrhosis as Per the Baveno VII Criteria

Status unknown Last updated 3 April 2024
What this trial tests

trial testing Other in Decompensated Cirrhosis in 50 participants. Status unknown.

Timeline
7 April 2024
Primary endpoint
31 March 2026
31 March 2026

Quick facts

Lead sponsorInstitute of Liver and Biliary Sciences, India
StatusStatus unknown
Study typeOBSERVATIONAL
Enrollment50
Start date7 April 2024
Primary completion31 March 2026
Estimated completion31 March 2026
Sites1 location across India

Drugs / interventions tested

Conditions studied

Sponsor

Institute of Liver and Biliary Sciences, India

Who can join

Adults 3 Months to 18, any sex, with Decompensated Cirrhosis. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

Cirrhosis is a leading cause of morbidity and mortality world- wide and can develop on the basis of repetitive and/or chronic liver injury due to toxic, infectious, metabolic and genetic pathogenic factors. Traditionally, the natural history of cirrhosis has often been considered a one-way street, with a definite and irreversible progression from a compensated to a decompensated disease stage. But recent data has shown that if the underlying etiology can be successfully treated, cirrhosis can regress and recompensation of liver disease can occur. Hence, in this study we want to evaluate the incidence and predictive factors of recompensation in pediatric subjects with decompensated cirrhosis as per the Baveno VII criteria. We would also evaluate the predictive factors of recompensation in pediatric decompensated chronic liver disase (DCLD) subjects and would explore systemic and intestinal inflammatory markers as possible biomarkers for predicting recompensation in pediatric subjects with decompensated cirrhosis.

Publications & conference data

No peer-reviewed publications indexed yet for this trial.

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