Last reviewed · How we verify
NCT06343363: EARLY-Edge
Early Discharge After Mitral and Tricuspid Edge-to-edge Repair: an Assessment of Feasibility and Safety
trial testing Early discharge protocol in Mitral Regurgitation in 127 participants. Completed in 11 February 2025.
11 February 2025
Quick facts
| Lead sponsor | Oxford University Hospitals NHS Trust |
|---|---|
| Status | Completed |
| Study type | OBSERVATIONAL |
| Enrollment | 127 |
| Start date | 1 May 2023 |
| Primary completion | 11 February 2025 |
| Estimated completion | 11 February 2025 |
| Sites | 1 location across United Kingdom |
Drugs / interventions tested
- Early discharge protocol
Conditions studied
- Mitral Regurgitation — all drugs for Mitral Regurgitation →
- Tricuspid Regurgitation — all drugs for Tricuspid Regurgitation →
- Mitral Repair — all drugs for Mitral Repair →
- Heart Failure — all drugs for Heart Failure →
Sponsor
Oxford University Hospitals NHS Trust
Who can join
18 and older, any sex, with Mitral Regurgitation or Tricuspid Regurgitation. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
Mitral regurgitation (MR) and tricuspid regurgitation (TR) are common causes of breathlessness, fluid retention and other heart failure symptoms, which lead to reduced quality of life and frequent hospitalisation. These conditions are particularly prevalent in older adults with many of these patients being at high risk for surgical intervention due to frailty and comorbidities, leaving them with few treatment alternatives. Transcatheter edge-to-edge repair (TEER) procedures have increasingly been used to improve the severity of both MR and TR, offering patients symptomatic relief and reductions in heart failure hospitalisation at low procedural risk. There is considerable geographic variation in protocols to assess these patients prior to the procedure and also in length of hospital stay. The standard of care in the UK, and particularly in Oxford, emphasises fewer investigations before the TEER procedure and shorter length of hospital stay. This prospective, observational cohort study will examine the safety and feasibility of this practice.
Publications & conference data
No peer-reviewed publications indexed yet for this trial. Completed trials usually publish results within 12-18 months.
Verify or expand the search:
- PubMed search for NCT06343363
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
Related trials
Other recruiting trials for Mitral Regurgitation
Currently open trials in the same condition.
- NCT07450911 — A Clinical Study Evaluating the Replacement of the Native Mitral Valve Using the ReValve System · Phase 1 · recruiting
- NCT07366723 — The Role of cardIac magNeTic rEsonance in surGical Decision Making in Patients With Severe pRimAry miTral rEgurgitation · NA · active not recruiting
- NCT07007143 — STrategies for Antithrombotic tReatment Following Transcatheter Edge-to-Edge Repair in Patients Without an Indication fo · Phase 4 · recruiting
- NCT07108907 — Outcome Registry and Assessment of New Edge-to-Edge Repair · recruiting
- NCT06901466 — STrategies for Antithrombotic tReatment Following Transcatheter Edge-to-Edge Repair in Patients With an Indication for O · Phase 4 · recruiting
Other Oxford University Hospitals NHS Trust trials
Trials by the same sponsor.
- NCT07303582 — Individualised Cryoneurolysis to Treat Pain in the Context of Spasticity in the Upper and Lower Extremities · Phase 4 · recruiting
- NCT06922695 — Responding to AF: Pill-in-Pocket Anticoagulation Guided by Automated Monitoring and Alerts · NA · recruiting
- NCT06822686 — Autologous Stem Cells in the Management of Fistulating Perianal Crohn's Disease · NA · not yet recruiting
- NCT06397664 — The Impact of Chronic Adolescent Skin Conditions on Sexual Health · completed
- NCT06130397 — AI Assisted Detection of Fractures on X-Rays (FRACT-AI) · completed
Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT06343363 (US National Library of Medicine, public domain)
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by Oxford University Hospitals NHS Trust
- Last refreshed: 17 June 2025
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT06343363.
Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing