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NCT06340516
NT-proBNP to Assess Trastuzumab-induced Cardiotoxicity
NA trial testing Plasma NT-proBNP in Cardiotoxicity in 700 participants. Currently enrolling.
14 March 2029
Quick facts
| Lead sponsor | Vastra Gotaland Region |
|---|---|
| Phase | NA |
| Status | Recruiting now |
| Study type | INTERVENTIONAL |
| Allocation | na |
| Design | single group |
| Masking | none |
| Primary purpose | diagnostic |
| Enrollment | 700 |
| Start date | 14 March 2024 |
| Primary completion | 14 March 2029 |
| Estimated completion | 14 March 2029 |
| Sites | 1 location across Sweden |
Drugs / interventions tested
- Plasma NT-proBNP
Conditions studied
- Cardiotoxicity — all drugs for Cardiotoxicity →
- Breast Cancer — all drugs for Breast Cancer →
- Treatment Side Effects — all drugs for Treatment Side Effects →
Sponsor
Vastra Gotaland Region — full company profile →
Who can join
18 and older, any sex, with Cardiotoxicity or Breast Cancer. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
Trastuzumab-induced cardiotoxicity (TIC) will be monitored in patients with HER2+ breast cancer undergoing trastuzumab treatment before and after breast cancer surgery. At baseline before start of trastuzumab treatment, echocardiography (ECHO)/multigated Acquisition Scan (MUGA) and measurement of plasma NT-proBNP will be performed. NT-proBNP will be measured again at 6 months and at 12 months of trastuzumab treatment. If elevations in NT-proBNP at 6 months and 12 months occur patients will be referred for ECHO/MUGA. The aim is to assess the sensitivity and specificity to detect TIC with NT-proBNP and whether ECHO/MUGA can be safely replaced by assessment of plasma NT-proBNP levels.
Publications & conference data
No peer-reviewed publications indexed yet for this trial.
Verify or expand the search:
- PubMed search for NCT06340516
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
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Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT06340516 (US National Library of Medicine, public domain)
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by Vastra Gotaland Region
- Last refreshed: 1 April 2024
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT06340516.
Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing