Ma-Spore ALL-Seq 2020: RNA-Seq and IgH/TCR-Seq to Improve Risk Assignment in Childhood, Adolescent and Young Adult Acute Lymphoblastic Leukaemia

NCT06336395 Phase 2 RECRUITING

The primary objective of this trial is to improve the overall survival rate of children and young adult with B-lineage acute lymphoblastic leukemia (B-ALL) in Singapore and Malaysia in the context of a multicenter cooperative trial using a risk-stratified therapy.

Details

Lead sponsor	National University Hospital, Singapore
Phase	Phase 2
Status	RECRUITING
Enrolment	500
Start date	2020-03-04
Completion	2030-03

Conditions

• B Lymphoblastic Leukemia

Interventions

• Prednisolone
• Dexamethasone
• Vincristine
• Methotrexate
• L-Asparaginase
• Pegylated asparaginase
• Erwinase
• Dasatinib
• Imatinib
• Cyclophosphamide

Primary outcomes

• Overall survival (OS) — 5 years from diagnosis
  OS is calculated from the date of diagnosis to the date of last follow-up or any death

Countries

Malaysia, Singapore