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NCT06335199
tVNS Responsiveness Testing With Pupil Size
NA trial testing Unilateral Left tVNS stimulation in Stroke in 21 participants. Completed in 27 October 2025.
27 October 2025
Quick facts
| Lead sponsor | Georgia Institute of Technology |
|---|---|
| Phase | NA |
| Status | Completed |
| Study type | INTERVENTIONAL |
| Allocation | randomized |
| Design | single group |
| Masking | double |
| Primary purpose | basic science |
| Enrollment | 21 |
| Start date | 14 November 2024 |
| Primary completion | 27 October 2025 |
| Estimated completion | 27 October 2025 |
| Sites | 1 location across United States |
Drugs / interventions tested
- Unilateral Left tVNS stimulation
- Bilateral tVNS stimulation
- Unilateral Left Sham stimulation
- Bilateral Sham stimulation
- Unilateral Right tVNS stimulation
- Unilateral Right Sham stimulation
Conditions studied
- Stroke — all drugs for Stroke →
Sponsor
Georgia Institute of Technology
Who can join
Adults 18 to 89, any sex, with Stroke. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
The goal of this study is to learn about the acute pupil response to transcutaneous vagus nerve stimulation (tVNS) in stroke survivors and healthy adults. The main question it aims to answer is whether pupil size response is greater with bilateral tVNS compared to unilateral tVNS. Participants will receive tVNS and sham at the outer ear unilaterally and bilaterally in resting condition. The pupil size of the participants will be recorded during tVNS.
Publications & conference data
No peer-reviewed publications indexed yet for this trial. Completed trials usually publish results within 12-18 months.
Verify or expand the search:
- PubMed search for NCT06335199
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
Related trials
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Other Georgia Institute of Technology trials
Trials by the same sponsor.
- NCT06064604 — Clinical Efficacy of Exoskeleton Assistance for Individuals Post-Stroke · NA · not yet recruiting
- NCT06648460 — Multimodal Differences in Effort-based Decision-Making in Depression · NA · not yet recruiting
- NCT06647082 — Engaging Kids With Robotic Exoskeletons and Gamification · NA · not yet recruiting
- NCT07128901 — Lower-Limb Exoskeleton Technology for Non-Ambulatory Individuals With Spinal Cord Injury · NA · recruiting
- NCT06323954 — tVNS During Motor Training in Older Adults · NA · recruiting
Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT06335199 (US National Library of Medicine, public domain)
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by Georgia Institute of Technology
- Last refreshed: 29 October 2025
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT06335199.
Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing