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NCT06329739

Genetics in Parkinson's Disease: Behavioral and Cognitive Outcomes

Recruiting now Last updated 26 March 2024
What this trial tests

trial testing Clinical examinations and clinical scales administration in Parkinson Disease in 68 participants. Currently enrolling.

Timeline
14 December 2021
Primary endpoint
14 December 2031
14 December 2031

Quick facts

Lead sponsorFondazione IRCCS Ca' Granda, Ospedale Maggiore Policlinico
StatusRecruiting now
Study typeOBSERVATIONAL
Enrollment68
Start date14 December 2021
Primary completion14 December 2031
Estimated completion14 December 2031
Sites1 location across Italy

Drugs / interventions tested

Conditions studied

Sponsor

Fondazione IRCCS Ca' Granda, Ospedale Maggiore Policlinico

Who can join

18 and older, any sex, with Parkinson Disease. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

The genetic landscape of Parkinson's disease (PD) is characterised by rare high penetrance pathogenic variants causing familial disease, genetic risk factor variants driving PD risk in a significant minority in PD cases and high frequency, low penetrance variants, which contribute a small increase of the risk of developing sporadic PD. This knowledge has the potential to have a major impact in the clinical care of people with PD. The goal of this observational study is to evaluate the impact of genetic mutation on behavior and cognition in PD patients. Patients will be assessed over time using test, questionnaire and standardised clinica scales. An initial assessment and annual follow-up assessments will be carried out for 5 years. Researchers will compare data collected from patients with genetic mutation versus patients without mutation.

Publications & conference data

1 peer-reviewed publication reference this trial (live from Europe PMC):

  1. Should old acquaintance be forgot: A call for recognition and inclusion of advanced Parkinson's disease patients & care partners in evolving research models.
    Park JS, Pensyl C, Manak TJ, Fleisher JE. · · 2025 · PMID 40645862 · DOI 10.1016/j.parkreldis.2025.107949

Verify or expand the search:

Other trials of Clinical examinations and clinical scales administration

Trials testing the same drug.

Other recruiting trials for Parkinson Disease

Currently open trials in the same condition.

Other Fondazione IRCCS Ca' Granda, Ospedale Maggiore Policlinico trials

Trials by the same sponsor.

Verify against primary sources

Data sources for this page

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