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NCT06315777
GREM1, HAS2 and PTGS2 Gene Expression Following the in Vitro Maturation (IVM)
NA trial testing cumulus cell oocytes complex (COC) among women with poor ovarian reserve in Increased Oocyte Death in 30 participants. Status unknown.
1 July 2024
Quick facts
| Lead sponsor | National University of Malaysia |
|---|---|
| Phase | NA |
| Status | Status unknown |
| Study type | INTERVENTIONAL |
| Allocation | na |
| Design | single group |
| Masking | none |
| Primary purpose | basic science |
| Enrollment | 30 |
| Start date | 1 July 2021 |
| Primary completion | 1 July 2024 |
| Estimated completion | 31 July 2024 |
| Sites | 1 location across Malaysia |
Drugs / interventions tested
- cumulus cell oocytes complex (COC) among women with poor ovarian reserve
Conditions studied
- Increased Oocyte Death — all drugs for Increased Oocyte Death →
- in Vitro Maturation — all drugs for in Vitro Maturation →
- GREM1 Gene Mutation — all drugs for GREM1 Gene Mutation →
- Cumulus Cell — all drugs for Cumulus Cell →
Sponsor
National University of Malaysia
Who can join
Adults 18 to 45, female only, with Increased Oocyte Death or in Vitro Maturation. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
Poor ovarian reserve (POR) is an adverse prognostic factor for In-Vitro Fertilization (IVF) success. Numerous established data showed low live birth rates per IVF cycle; 6 to 10%, including the usage of In-Vitro Maturation (IVM). In Malaysia, POR incidence increases mainly from cancer survival, endometriosis, and autoimmune diseases women; therefore, IVM implementation is paramount. In the molecular level, the low competence oocytes showed a low expression of GREM1, HAS2 and PTGS2 in human cumulus cells, thus leading to poor oocyte quality(OQ). Various IVM media had been formulated to enhance the competency and quality of the oocytes to date. Therefore, our study aims to elucidate the GREM1, HAS2 and PTGS2 gene expression as oocyte developmental competency markers among POR women following IVM and tailored to the IVF outcome.
Publications & conference data
No peer-reviewed publications indexed yet for this trial.
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Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT06315777 (US National Library of Medicine, public domain)
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by National University of Malaysia
- Last refreshed: 18 March 2024
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