Last reviewed · How we verify
NCT06298045
Effectiveness of a Combination of Trimetazidine With One Hemodynamic Agent in Patients Recently Diagnosed With Stable Angina and Still Symptomatic Despite First Line Hemodynamic Therapy
trial in Stable Angina in 600 participants. Status unknown.
31 March 2025
Quick facts
| Lead sponsor | Servier Affaires Médicales |
|---|---|
| Status | Status unknown |
| Study type | OBSERVATIONAL |
| Enrollment | 600 |
| Start date | 15 July 2023 |
| Primary completion | 31 March 2025 |
| Estimated completion | 31 March 2025 |
| Sites | 1 location across Romania |
Conditions studied
- Stable Angina — all drugs for Stable Angina →
Sponsor
Servier Affaires Médicales — full company profile →
Who can join
18 and older, any sex, with Stable Angina. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
The purpose of this study is to assess in recently diagnosed stable Angina patients symptomatic despite first line hemodynamic therapy, the effect of a combination of this hemodynamic agent with a metabolic one (trimetazidine). The treatment effect will be measured by the reduction of patients' angina symptoms, physical limitation and an improvement of quality of life using the Seattle Angina Questionnaire-7 items (SAQ-7) Patients will be also proposed to complete a BEAMER (BEhavioral and Adherence Model for improving quality, health outcomes and cost-Effectiveness of healthcaRe) questionnaire which will contribute to a separate research project developed by the Innovative Medicines Initiative (IMI). Analysis of the BEAMER questionnaires will be performed outside the study by the IMI BEAMER Consortium for BEAMER purposes only.
Publications & conference data
1 peer-reviewed publication reference this trial (live from Europe PMC):
-
Early combination therapy with trimetazidine rapidly improves symptoms and quality of life in patients recently diagnosed with stable angina: The COMBINE angina study.
Marzilli M, Gowdak LHW, Sobhy M, Mittal S, et al · · 2026 · PMID 41308999 · DOI 10.1016/j.ijcard.2025.134050
Verify or expand the search:
- PubMed search for NCT06298045
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
Related trials
Other recruiting trials for Stable Angina
Currently open trials in the same condition.
- NCT06436092 — Japanese Coronary Intervention Using Drug Eluting and Perfusion Therapy for Left Main Disease (JDEPTH-LM Registry) · recruiting
- NCT05972070 — Integration of Telemedicine and Home-Based Cardiac Rehabilitation: Feasibility, Efficacy, and Adherence · recruiting
- NCT05865600 — Perfusion Estimation For Optimal Treatment Strategy in Chronic Coronary Syndrome · NA · recruiting
- NCT05230446 — PRospective Evaluation of Complete Revascularization in Patients With multiveSsel Disease Excluding chroNic Total Occlus · NA · recruiting
- NCT05255705 — Barts Revascularisation Registry · recruiting
Other Servier Affaires Médicales trials
Trials by the same sponsor.
- NCT06155136 — RWE on Patients With mPDAC Long-term Survival After Treatment With Liposomal Irinotecan · active not recruiting
- NCT05907057 — An Open-label Phase 3b Study of Ivosidenib in Combination With Azacitidine in Adult Patients Newly Diagnosed With IDH1m · Phase 3 · recruiting
- NCT05876754 — An Early Access Study of Ivosidenib in Patients With a Pretreated Locally Advanced or Metastatic Cholangiocarcinoma · Phase 3 · recruiting
- NCT06704815 — Observational Cohort Study Evaluating the Effectiveness of an Educational Program (NGAYDAUTIEN) in Combination With Peri · completed
- NCT06704802 — Observational Cohort Study Evaluating the Effectiveness of an Education Program (NGAYDAUTIEN) in Combination With Glicla · completed
Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT06298045 (US National Library of Medicine, public domain)
- Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by Servier Affaires Médicales
- Last refreshed: 7 March 2024
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT06298045.
Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing