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NCT06297538
Parkinson's Disease and Gamma-transcranial Alternating Current Stimulation
NA trial testing gamma transcranial alternating current stimulation (tACS) in Parkinson Disease in 84 participants. Currently enrolling.
29 October 2024
Quick facts
| Lead sponsor | Neuromed IRCCS |
|---|---|
| Phase | NA |
| Status | Recruiting now |
| Study type | INTERVENTIONAL |
| Allocation | randomized |
| Design | parallel |
| Masking | quadruple |
| Primary purpose | treatment |
| Enrollment | 84 |
| Start date | 29 April 2023 |
| Primary completion | 29 October 2024 |
| Estimated completion | 29 April 2026 |
| Sites | 1 location across Italy |
Drugs / interventions tested
- gamma transcranial alternating current stimulation (tACS)
- sham transcranial alternating current stimulation (tACS)
Conditions studied
- Parkinson Disease — all drugs for Parkinson Disease →
Sponsor
Neuromed IRCCS
Who can join
18 and older, any sex, with Parkinson Disease. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
Cortical-basal ganglia gamma oscillations are pathologically reduced in Parkinson's disease (PD) and the plasticity of the primary motor cortex (M1) is impaired. Enhancing gamma oscillations through transcranial alternating current stimulation (tACS), a non-invasive neurophysiological tool that modulates cortical rhythms, can restore this alteration. However, whether tACS-related normalization of M1 plasticity results in positive clinical effects is unknown. Motor learning is also impaired in PD and gamma oscillations play a relevant role in different forms of learning in humans. Nevertheless, whether motor learning abnormalities relate to reduced gamma oscillations in PD is another unclear issue. It can be hypothesized that gamma oscillations impairment in M1 contributes to altered motor control, plasticity and learning in PD. Accordingly, in this project, the authors intend to test whether gamma-tACS on M1 in PD patients ameliorates motor performance and learning, as objectively assessed with kinematic techniques.
Publications & conference data
1 peer-reviewed publication reference this trial (live from Europe PMC):
-
Driving motor cortex oscillations restores plasticity and improves bradykinesia features in Parkinson's disease.
Paparella G, Costa D, De Riggi M, Angelini L, et al · · 2026 · PMID 42115691 · DOI 10.1038/s41531-026-01373-0
Verify or expand the search:
- PubMed search for NCT06297538
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
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Other Neuromed IRCCS trials
Trials by the same sponsor.
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- NCT06900959 — Transcranial Static Field Stimulation (tSMS) and Transcranial Direct Current Stimulation (tDCS) for the Treatment of Neu · NA · not yet recruiting
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- NCT05784376 — The Southern Italian Children, Adolescents and PaRents COhort Study on Nutrition and Health · unknown
Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT06297538 (US National Library of Medicine, public domain)
- Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by Neuromed IRCCS
- Last refreshed: 7 March 2024
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT06297538.
Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing