Last reviewed · How we verify
NCT06297278: BRAINS
Exercise Facilitation of Adolescent Fear Extinction, Frontolimbic Circuitry, and Endocannabinoids
NA trial testing Moderate Intensity Exercise in Adolescence in 174 participants. Currently enrolling.
30 April 2028
Quick facts
| Lead sponsor | Wayne State University |
|---|---|
| Phase | NA |
| Status | Recruiting now |
| Study type | INTERVENTIONAL |
| Allocation | randomized |
| Design | parallel |
| Masking | none |
| Primary purpose | basic science |
| Enrollment | 174 |
| Start date | 17 May 2024 |
| Primary completion | 30 April 2028 |
| Estimated completion | 30 April 2028 |
| Sites | 1 location across United States |
Drugs / interventions tested
- Moderate Intensity Exercise
Conditions studied
- Adolescence — all drugs for Adolescence →
Sponsor
Wayne State University
Who can join
Adults 14 to 17, any sex, with Adolescence. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
Anxiety disorders commonly begin during adolescence, and are characterized by deficits in the ability to inhibit or extinguish pathological fear. Recent research has provided new understanding of how fear is learned and can be regulated in the adolescent brain, and how the endocannabinoid system shapes these processes; however, these advances have not yet translated into improved therapeutic outcomes for adolescents with anxiety. This study will test whether a behavioral intervention, acute exercise, can help to improve fear regulation by enhancing brain activity and endocannabinoid signaling. This line of research may ultimately lead to more effect treatments for adolescent anxiety, and to new preventive strategies for at-risk youth.
Publications & conference data
No peer-reviewed publications indexed yet for this trial.
Verify or expand the search:
- PubMed search for NCT06297278
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
Related trials
Other trials of Moderate Intensity Exercise
Trials testing the same drug.
- NCT06480695 — Exercise Training Intensity and Nitrate Supplementation in Post-Menopausal Females · NA · recruiting
- NCT06127342 — Exercise and Emotional Learning in Posttraumatic Stress Disorder · NA · recruiting
- NCT06808490 — Exercise and Endocannabinoids for Brain and Mental Health · NA · completed
- NCT04113798 — Exercise and Therapeutic Learning Among Women With PTSD · NA · completed
- NCT03400423 — The Acute Effects of Caffeine on Exercise and Cognition · Phase 4 · completed
Other recruiting trials for Adolescence
Currently open trials in the same condition.
- NCT07218588 — Sanctuary Farm Prescription in Adolescents · NA · recruiting
- NCT07517016 — Real-Time Pose Recognition Technology for Improving Tennis Learning in Individuals With Intellectual Disabilities · NA · active not recruiting
- NCT04753190 — Light Timing Study · NA · recruiting
Other Wayne State University trials
Trials by the same sponsor.
- NCT07219394 — Peer-Delivered Behavioral Activation in a CCBHC · NA · recruiting
- NCT07123467 — Cannabidiol-Assisted Learning for Managing Generalized Anxiety Disorder · Phase 3 · recruiting
- NCT07222306 — Cannabis, Neuroinflammation, and Suicidal Ideation: A Supplemental Brain Imaging Study · enrolling by invitation
- NCT05684978 — Efficacy and Safety of Perampanel in the Treatment of Refractory Status Epilepticus · Phase 4 · terminated
- NCT06381180 — Warrior CARE: Cannabis Behavioral Health · Phase 1, PHASE2 · not yet recruiting
Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT06297278 (US National Library of Medicine, public domain)
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by Wayne State University
- Last refreshed: 7 August 2025
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT06297278.
Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing