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NCT06291727
Mepivacaine vs Bupivacaine Spinal Anesthesia for TKA
Phase 4 trial testing Mepivacaine in Anesthesia, Spinal in 138 participants. Completed in 1 August 2025.
1 August 2025
Quick facts
| Lead sponsor | Prisma Health-Upstate |
|---|---|
| Phase | Phase 4 |
| Status | Completed |
| Study type | INTERVENTIONAL |
| Allocation | randomized |
| Design | parallel |
| Masking | double |
| Primary purpose | treatment |
| Enrollment | 138 |
| Start date | 16 February 2024 |
| Primary completion | 1 August 2025 |
| Estimated completion | 1 August 2025 |
| Sites | 1 location across United States |
Drugs / interventions tested
- Mepivacaine (MEPIVACAINE) — full drug profile →
- Bupivacaine (BUPIVACAINE) — full drug profile →
Conditions studied
- Anesthesia, Spinal — all drugs for Anesthesia, Spinal →
- Arthroplasty, Replacement, Knee — all drugs for Arthroplasty, Replacement, Knee →
Sponsor
Prisma Health-Upstate — full company profile →
Who can join
18 and older, any sex, with Anesthesia, Spinal or Arthroplasty, Replacement, Knee. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
This study is a prospective, double-blind prospective randomized controlled trial comparing mepivacaine and bupivacaine spinal anesthesia for same-day discharge readiness following a unilateral primary elective TKA procedure. Study data will be collected during the patient's hospital stay for their TKA procedure, and the primary outcome of same-day discharge readiness will be assessed the day of surgery. Patients will also be contacted at Day 3 post-op to assess for any complications, current level of pain, and pain medication utilization.
Publications & conference data
No peer-reviewed publications indexed yet for this trial. Completed trials usually publish results within 12-18 months.
Verify or expand the search:
- PubMed search for NCT06291727
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
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Other recruiting trials for Anesthesia, Spinal
Currently open trials in the same condition.
- NCT07050277 — Post-Operative Urinary Retention on Revision Knee Arthroplasty: the Role of Intrathecal Morphine · Phase 3 · recruiting
- NCT06878014 — Comparing the Safety and Effectiveness of Different Doses of Morphine Administered in Spinal Anethesia for Pain Relief A · Phase 4 · recruiting
- NCT05824338 — Testing the Feasibility of Using Ropivacaine in Spinal Anesthesia for Patients With Lower Back Surgery · EARLY_PHASE1 · recruiting
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- NCT06343259 — The Effects of General Versus Spinal Anesthesia on Postoperative Myocardial Injury · NA · recruiting
Other Prisma Health-Upstate trials
Trials by the same sponsor.
- NCT07202039 — Electronic Cigarettes as a Harm Reduction Strategy Among People With Opioid Use Disorder on Buprenorphine · NA · not yet recruiting
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- NCT07102615 — Intracervical Vasopressin · Phase 4 · recruiting
- NCT07101250 — Preoperative Acetazolamide · Phase 4 · recruiting
- NCT06874413 — Targeted Prehabilitation With Physical Exercise and Inspiratory Muscle Training for Elderly Frail Patients Prior to Vent · NA · enrolling by invitation
Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT06291727 (US National Library of Medicine, public domain)
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by Prisma Health-Upstate
- Last refreshed: 28 August 2025
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT06291727.
Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing