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NCT06288425: SPACE-KiT
Spatial Transcriptomics in Kidney Transplantation
trial testing Non interventional in Transplant Complication in 500 participants. Enrolling by invitation.
1 January 2030
Quick facts
| Lead sponsor | Western Sydney Local Health District |
|---|---|
| Status | ENROLLING BY INVITATION |
| Study type | OBSERVATIONAL |
| Enrollment | 500 |
| Start date | 3 April 2024 |
| Primary completion | 1 January 2030 |
| Estimated completion | 1 January 2035 |
| Sites | 1 location across Australia |
Drugs / interventions tested
- Non interventional
Conditions studied
- Transplant Complication — all drugs for Transplant Complication →
- Kidney Injury — all drugs for Kidney Injury →
Sponsor
Western Sydney Local Health District — full company profile →
Who can join
Adults 18 to 75, any sex, with Transplant Complication or Kidney Injury. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
The study is an investigator-led, prospective, longitudinal, observational cohort study. The central hypothesis for this study is that spatial data will reveal new insights to immune cell function and local interactions within the kidney tissue to better predict important clinical outcomes. Investigators aspire to establish a prospective, longitudinal cohort to improve the diagnosis and management of kidney transplant rejection using precision pathology. By utilising new spatial technologies, the investigators aim to: * Derive a spatially resolved transcriptomic signature of kidney transplant rejection subtypes * Derive accurate transcriptomic signatures aligned with key cell types within the transplant kidney * Develop refinements to histological kidney rejection diagnostic and scoring classification * Correlate of spatial and refined biopsy scoring features to clinically important outcomes
Publications & conference data
No peer-reviewed publications indexed yet for this trial.
Verify or expand the search:
- PubMed search for NCT06288425
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
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Other recruiting trials for Transplant Complication
Currently open trials in the same condition.
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Other Western Sydney Local Health District trials
Trials by the same sponsor.
- NCT07445334 — Catheter Ablation Versus Anti-arrhythmic Drugs for Premature Ventricular Complexes · NA · not yet recruiting
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- NCT06365411 — GEnomic Medicine in Kidney Transplantation Study · not yet recruiting
- NCT06828562 — GENomic Predictors in A Multi-Ethnic Population With Kidney Disease Study · enrolling by invitation
- NCT05509153 — A Randomised Controlled Trial, Of N-Acetyl Cysteine (NAC), for Premanifest Huntingtin Gene Expansion Carriers · Phase 2 · recruiting
Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT06288425 (US National Library of Medicine, public domain)
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by Western Sydney Local Health District
- Last refreshed: 24 April 2024
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT06288425.
Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing