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NCT06285760: SANDI
Effect of Acetazolamide on Diuresis and Natriuresis in Patients With Acute Heart Failure (SANDI STUDY)
trial testing Acetazolamide 500mg in Heart Failure in 64 participants. Currently enrolling.
31 May 2026
Quick facts
| Lead sponsor | Puerta de Hierro University Hospital |
|---|---|
| Status | Recruiting now |
| Study type | OBSERVATIONAL |
| Enrollment | 64 |
| Start date | 1 March 2024 |
| Primary completion | 31 May 2026 |
| Estimated completion | 31 December 2026 |
| Sites | 1 location across Spain |
Drugs / interventions tested
- Acetazolamide 500mg — full drug profile →
Conditions studied
- Heart Failure — all drugs for Heart Failure →
- Persistent Congestion — all drugs for Persistent Congestion →
Sponsor
Puerta de Hierro University Hospital
Who can join
Eligibility, any sex, with Heart Failure or Persistent Congestion. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
The goal of this observational study is to assess the natriuretic effect of intravenous acetazolamide in patients admitted with heart failure and persistent congestion despite treatment with intravenous furosemide and sodium-glucose cotransporter type 2 (iSGLT2) inhibitors. The main question it aims to answer is whether there is a difference in natriuresis 24 hours after acetazolamide association to medical treatment recommended by the guidelines (furosemide and ISGLT2).
Publications & conference data
1 peer-reviewed publication reference this trial (live from Europe PMC):
-
Acetazolamide effects on natriuresis and diuresis in acute heart failure treated with furosemide and SGLT2i (SANDI).
González González J, Górriz Magaña J, Llàcer P, Fort Pal A, et al · · 2026 · PMID 41920937 · DOI 10.1093/eschf/xvag096
Verify or expand the search:
- PubMed search for NCT06285760
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
Related trials
Other trials of Acetazolamide 500mg
Trials testing the same drug.
- NCT06783166 — Assessing the Clinical Outcomes of Dapagliflozin Versus Acetazolamide in Patients With Acute Heart Failure · Phase 2, PHASE3 · recruiting
Other recruiting trials for Heart Failure
Currently open trials in the same condition.
- NCT06118983 — Improving TRansitions ANd OutcomeS for Heart FailurE Patients in Home Health CaRe (I-TRANSFER-HF) · NA · recruiting
- NCT07496372 — Efficacy and Safety of Human Induced Pluripotent Stem Cell-Derived Cardiomyocyte Injection (HiCM-188) in Advanced Heart · Phase 3 · recruiting
- NCT07527156 — Prolonged Nasogastric Administration of Ketones in Decompensated Heart Failure · Phase 4 · recruiting
- NCT07263035 — Urine Sodium-Driven Diuretic Adjustment Strategy in Acute Decompensated Heart Failure · Phase 4 · recruiting
- NCT07531966 — Vascular Complications After Kidney Transplantation · recruiting
Other Puerta de Hierro University Hospital trials
Trials by the same sponsor.
- NCT07509346 — Fecal Microbiota Transplant vs Standard Treatment for Recurrent Non-Obstructive Cholangitis · Phase 2 · not yet recruiting
- NCT07281248 — TRIMODAL PREHABILITATION IN GASTROINTESTINAL CANCER · NA · recruiting
- NCT07008729 — Heart Failure Patient Management and Interventions Using Continuous Patient Monitoring Outside Hospitals and Real-world · NA · active not recruiting
- NCT06293495 — Incidence of Cut-out Using Intramedullary Nails With Double Cephalic Screw vs. Unique in Pertrochanteric Fractures · NA · unknown
- NCT06115109 — Angelman Natural History Study - FAST Spain · recruiting
Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT06285760 (US National Library of Medicine, public domain)
- Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by Puerta de Hierro University Hospital
- Last refreshed: 29 December 2025
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT06285760.
Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing