NCT06282705

Dose Response Effect of Drop Jumps on Bone Characteristics

Completed NA Last updated 28 February 2024

What this trial tests

NA trial testing Diagonal Drop Jumps 0cm in Healthy Participants in 48 participants. Completed in 13 December 2023.

Timeline

6 January 2023

Primary endpoint
13 December 2023

13 December 2023

Quick facts

Lead sponsor	Nottingham Trent University
Phase	NA
Status	Completed
Study type	INTERVENTIONAL
Allocation	randomized
Design	parallel
Masking	none
Primary purpose	basic science
Enrollment	48
Start date	6 January 2023
Primary completion	13 December 2023
Estimated completion	13 December 2023
Sites	1 location across United Kingdom

Drugs / interventions tested

• Diagonal Drop Jumps 0cm
• Diagonal Drop Jumps 40cm
• Diagonal Drop Jumps 60cm

Conditions studied

• Healthy Participants — all drugs for Healthy Participants →
• Low Activity Level — all drugs for Low Activity Level →

Sponsor

Nottingham Trent University

Who can join

Adults 18 to 25, any sex, with Healthy Participants or Low Activity Level. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

The study aims to assess if a 16-week drop jump intervention from different heights shows different bone adaptations. Participants will complete four visits over a period of 16 weeks. An initial consultation will be conducted to ensure participants meet the inclusion criteria following participant recruitment. Estimated load being applied to the bone, will be assessed using non-invasive biomechanical procedures (Inertial Measurement Units, motion analysis, force plates) during drop jumps. Participants will be assigned a drop jump height of 0 cm, 30 cm or 60 cm based on a significant difference in external load at these heights or assigned to a control group where no jumps will be performed. Groups will be matched for body mass to ensure that jump height produces the load. The participants will be asked to perform 40 jumps (20 each side), 4 times per week ensuring jumping bouts are separated by 24 hours. Bone characteristics will be assessed via whole body dual-energy X-ray absorptiometry (DXA) scans and bilateral peripheral Quantitative Computed Tomography (pQCT) scans. Lab based jumping will take place on week 0, week 6, week 12, and week 16 to understand the loading applied during the different jump height groups. pQCT scans will take place on week 0, week 12, week 16 and DXA scans will take place week 0 and week 16. The reasoning of week 12 for pQCT being it may show a significant timepoint for bone formation during the remodelling cycle. During visits participants will complete a health screen, the Bone specific Physical Activity Questionnaire (BPAQ), a food frequency questionnaire and Pittsburgh sleep quality questionnaire alongside consent as tools to monitor any changes to participant lifestyle across the study. Differences in bone characteristics, lab measures and jump heights will be analysed between and within participants.

The present study aims to use varied drop jump heights to identify an osteogenic dose response effect. Drop jumps have been previously used to expose osteogenic effects in research due to the load produced at impact. Is it possible to identify an optimum height for bone response during impact? If so do we then find anything above this height actually has negative or no effect on a group of individuals?

Publications & conference data

No peer-reviewed publications indexed yet for this trial. Completed trials usually publish results within 12-18 months.