Last reviewed · How we verify
Pathogenetic Risk Factors for Corneal Graft Rejection in Penetrating Keratoplasty Patients
There are many predictors that may influence the development of corneal graft rejection after penetrating keratoplasty. In our study investigators analysed the results of keratoplasty and the risk factors for graft rejection. Investigators analysed data from 493 patients who underwent penetrating keratoplasty between 2011 and 2019. Keratoplasty outcomes were followed up at subsequent clinic visits until December 2021. Then, 93 medical records were selected (taking into account the completeness of the medical records) and divided into two groups based on the primary diagnosis that was an indication for keratoplasty: high-risk and low-risk patients. Investigators then estimated the survival time (clear graft) of the corneal graft using Kaplan-Meier statistical survival analysis. Investigators also investigated the factors that influence corneal graft opacity.
Details
| Lead sponsor | The S.N. Fyodorov Eye Microsurgery State Institution |
|---|---|
| Status | COMPLETED |
| Enrolment | 93 |
| Start date | 2011-01 |
| Completion | 2019-01 |
Conditions
- Graft Rejection
Interventions
- penetrating keratoplasty
Primary outcomes
- Cohort group Kaplan-Meier survival analysis (clear graft engraftment) — 2011-2019
Investigators used Kaplan-Meier survival analysis to evaluate the survival (clear graft) of the corneal graft in this cohort.
Countries
Russia