NCT06280274 is a Phase 4 clinical trial of Metformin in Hyperglycemia, sponsored by Oregon Health and Science University.

Who is sponsoring NCT06280274?

NCT06280274 is sponsored by Oregon Health and Science University.

What drugs are being tested in NCT06280274?

Interventions in NCT06280274: Metformin, Placebo.

What condition does NCT06280274 study?

NCT06280274 studies Hyperglycemia.

Is NCT06280274 still recruiting?

NCT06280274 is currently completed. Last updated 5 December 2025.

Last reviewed 2025-12-05 · How we verify

NCT06280274

Name: Drug Landscape Pharmaceutical Database
Creator: Drug Landscape
Published: 2026-01-01
License: https://creativecommons.org/licenses/by/4.0/

Metformin Use in Patients Undergoing Total Joint Replacement Surgery

Completed Phase 4 Last updated 5 December 2025

What this trial tests

Phase 4 trial testing Metformin in Hyperglycemia in 40 participants. Completed in 15 September 2025.

Timeline

27 June 2024

Primary endpoint
15 September 2025

15 September 2025

Quick facts

Lead sponsor	Oregon Health and Science University
Phase	Phase 4
Status	Completed
Study type	INTERVENTIONAL
Allocation	randomized
Design	parallel
Masking	single
Primary purpose	treatment
Enrollment	40
Start date	27 June 2024
Primary completion	15 September 2025
Estimated completion	15 September 2025
Sites	1 location across United States

Drugs / interventions tested

Metformin (metformin) — full drug profile →
Placebo

Conditions studied

Hyperglycemia — all drugs for Hyperglycemia →

Sponsor

Oregon Health and Science University

Who can join

Adults 18 to 99, any sex, with Hyperglycemia. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

The goal of this pilot, randomized, single-blind, placebo-controlled trial is to evaluate the feasibility of and provide preliminary information for a multi-center randomized controlled trial that will assess the effects of metformin on blood sugar control in patients after total hip or total knee replacement surgery. The primary objective of this study is to assess the feasibility of conducting a large, randomized trial with regards to timely recruitment, study drug administration, protocol adherence, and overall retention in patients undergoing total joint arthroplasty. Secondarily, the investigators aim to obtain preliminary estimates of group-specific outcome means and variances for primary and secondary outcomes of a larger future trial.

Publications & conference data

2 peer-reviewed publications reference this trial (live from Europe PMC):

Immunometabolism, an emerging field in perioperative and critical care medicine: a narrative review.
Nessel I, Tsang VSK, Schroth J, Janssen H. · · 2026 · cited 1× · PMID 41638974 · DOI 10.1016/j.bja.2026.01.003
Perioperative metformin use in patients undergoing total joint replacement surgery: protocol for a randomised, placebo-controlled pilot study.
Morrell A, Shelofsky S, Hoffman H, McCallister C, et al · · 2025 · PMID 40204318 · DOI 10.1136/bmjopen-2024-091446

Verify or expand the search:

Other trials of Metformin

Trials testing the same drug.

NCT07275359 — Investigating Senolytic Properties in Pulmonary Rehabilitation and Metformin in COPD Exacerbations · Phase 1 · not yet recruiting
NCT07520110 — Metformin to Attenuate Progressive Respiratory Decline in Idiopathic Pulmonary Fibrosis · Phase 3 · not yet recruiting
NCT07007221 — Clinical Trials to Evaluate Metformin to Treat Depression in People Living With HIV · Phase 2 · not yet recruiting
NCT07585396 — Inositol in Letrozol Resistant PCOS Women · Phase 2, PHASE3 · not yet recruiting
NCT07226453 — Target Validation and Efficacy of Metformin in Patients With Posterior Fossa Group A (PFA) Ependymoma · Phase 2 · not yet recruiting

Other recruiting trials for Hyperglycemia

Currently open trials in the same condition.

NCT06893341 — Monitoring Exhaled Breath to Noninvasively Detect Glycemic Events · NA · recruiting
NCT06118931 — Time-restricted Eating, Window Timing, Type 2 Diabetes Status and Sex on Glycemic Control · NA · recruiting
NCT06184373 — Early Investigation of Glucose Monitoring After Gestational Diabetes Pilot · recruiting
NCT07400549 — Prospective Exploratory Study on the Comprehensive Application Effectiveness of Exercise Prescription Decision Support T · NA · recruiting
NCT06694012 — Osaka Cardiometabolic Epidemiological Study: Ohtori Study Part 2 · recruiting

Other Oregon Health and Science University trials

Trials by the same sponsor.

NCT07431970 — Assessing Construction Execution Under Sleep Impairment · NA · not yet recruiting
NCT07309757 — Maternal Outcomes With Methamphetamine Use and Cardiac Assessment for Rural Dissemination (MOM CARD) · not yet recruiting
NCT07282639 — App-Based Certified Diabetes Education Therapy (AB-CDE) · NA · not yet recruiting
NCT07322588 — Reentry Incentives and Support for Engagement With Contingency Management · NA · not yet recruiting
NCT07220590 — Implementing Powered Mobility in Early Childhood Settings for Children With Cerebral Palsy · NA · not yet recruiting

Verify against primary sources

ClinicalTrials.gov — authoritative US registry record
WHO ICTRP — international registry index
EU Clinical Trials Register
Sponsor press releases (Google)

Data sources for this page

Trial protocol + status: ClinicalTrials.gov NCT06280274 (US National Library of Medicine, public domain)
Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
Sponsor: as reported to ClinicalTrials.gov by Oregon Health and Science University
Last refreshed: 5 December 2025

Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT06280274.

Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing