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NCT06279325
Effects of a Computerized Cognitive Stimulation Intervention Adapted to the Level of Cognitive Reserve
NA trial testing Computerized cognitive stimulation program in Mild Cognitive Impairment in 100 participants. Currently enrolling.
31 May 2024
Quick facts
| Lead sponsor | Universidad de Zaragoza |
|---|---|
| Phase | NA |
| Status | Recruiting now |
| Study type | INTERVENTIONAL |
| Allocation | randomized |
| Design | parallel |
| Masking | single |
| Primary purpose | supportive care |
| Enrollment | 100 |
| Start date | 1 April 2024 |
| Primary completion | 31 May 2024 |
| Estimated completion | 15 January 2025 |
| Sites | 1 location across Spain |
Drugs / interventions tested
- Computerized cognitive stimulation program
- Face-to-face training-explanatory session
Conditions studied
- Mild Cognitive Impairment — all drugs for Mild Cognitive Impairment →
- Cognitive Dysfunction — all drugs for Cognitive Dysfunction →
Sponsor
Universidad de Zaragoza — full company profile →
Who can join
60 and older, any sex, with Mild Cognitive Impairment or Cognitive Dysfunction. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
Normal ageing presents subtle cognitive changes that can be detected before meeting the criteria for Mild cognitive impairment (MCI). Older people with low cognitive reserve and who receive limited cognitive stimulation are at greater risk of deterioration. In this regard, cognitive stimulation (CS) has been identified as an intervention that reduces this risk, provided that its design considers the differences in the level of cognitive reserve (CR) acquired throughout life and the baseline level of cognitive functioning. The general objective of this study is to evaluate, through a randomized clinical trial, the effectiveness of a computerized cognitive stimulation program, designed and adapted from Occupational Therapy based on the level of cognitive reserve in older adults in Primary Care. 100 participants will be randomized in a stratified manner according to the level of cognitive reserve (high/low), assigning 50 participants to the control group and 50 participants to the intervention group. The intervention group will carry out a computerized cognitive stimulation intervention designed and adapted from occupational therapy according to the level of cognitive reserve, through the "stimulus" platform. The main result expected to be achieved is the improvement of higher brain functions. As secondary results, the investigators expect that those cognitive aspects most vulnerable to ageing will decrease more slowly (in areas such as memory, executive function, attention and processing speed) and that the cognitive reserve of the participants will increase, in addition to being able to balance gender differences in these aspects. The investigators think that these results can positively impact the creation of adapted, meaningful and stimulating CS programs in older adults to prevent MCI and experience healthier ageing.
Publications & conference data
1 peer-reviewed publication reference this trial (live from Europe PMC):
-
Digital Competence and Cognitive Reserve in Relation to Different Domains of Cognitive Functioning in Older Adults and Factors Modulating This Association: A Cross-Sectional Study of a Randomized Clinical Trial.
Calatayud E, Oliván-Blázquez B, Aguilar-Latorre A, Cuenca-Zaldivar JN, et al · · 2025 · cited 1× · PMID 41060253 · DOI 10.1111/ggi.70199
Verify or expand the search:
- PubMed search for NCT06279325
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
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Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT06279325 (US National Library of Medicine, public domain)
- Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by Universidad de Zaragoza
- Last refreshed: 12 December 2024
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT06279325.
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