Early Neutropenic Fever De-escalation of Antibiotics Study (END)

NCT06278896 PHASE3 NOT_YET_RECRUITING

This is a randomized, open label clinical trial among individuals with hematologic conditions. The trial aims to evaluate the safety and clinical outcomes of de-escalating antibiotic therapy among stable individuals diagnosed with neutropenic fever, in which no bacterial infection has been identified.

Details

Lead sponsor	Brigham and Women's Hospital
Phase	PHASE3
Status	NOT_YET_RECRUITING
Enrolment	260
Start date	Fri Mar 01 2024 00:00:00 GMT+0000 (Coordinated Universal Time)
Completion	Wed Mar 01 2028 00:00:00 GMT+0000 (Coordinated Universal Time)

Conditions

• Hematologic Malignancy
• Febrile Neutropenia
• Antibiotic Stewardship

Interventions

• Cessation of antibiotics