NCT06277739 is a NA clinical trial of Spinal Manipulative Therapy in Lumbar Disc Herniation, sponsored by Zhou Xingchen.

Who is sponsoring NCT06277739?

NCT06277739 is sponsored by Zhou Xingchen.

What drugs are being tested in NCT06277739?

Interventions in NCT06277739: Spinal Manipulative Therapy, Sham Laser Treatment.

What condition does NCT06277739 study?

NCT06277739 studies Lumbar Disc Herniation.

Is NCT06277739 still recruiting?

NCT06277739 is currently completed. Last updated 15 June 2025.

Last reviewed 2025-06-15 · How we verify

NCT06277739

Name: Drug Landscape Pharmaceutical Database
Creator: Drug Landscape
Published: 2026-01-01
License: https://creativecommons.org/licenses/by/4.0/

Brain Effect Mechanism of Spinal Manipulative Therapy on LDH Analgesia Based on Multimodal MRI

Completed NA Last updated 15 June 2025

What this trial tests

NA trial testing Spinal Manipulative Therapy in Lumbar Disc Herniation in 90 participants. Completed in 1 May 2025.

Timeline

1 June 2022

Primary endpoint
1 May 2025

1 May 2025

Quick facts

Lead sponsor	Zhou Xingchen
Phase	NA
Status	Completed
Study type	INTERVENTIONAL
Allocation	randomized
Design	parallel
Masking	single
Primary purpose	treatment
Enrollment	90
Start date	1 June 2022
Primary completion	1 May 2025
Estimated completion	1 May 2025
Sites	1 location across China

Drugs / interventions tested

Spinal Manipulative Therapy
Sham Laser Treatment

Conditions studied

Lumbar Disc Herniation — all drugs for Lumbar Disc Herniation →

Sponsor

Zhou Xingchen

Who can join

Adults 18 to 65, any sex, with Lumbar Disc Herniation. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

The clinical symptoms of Lumbar Disc Herniation (LDH) can be effectively ameliorated through Spinal Manipulative Therapy (SMT), which is closely linked to the brain's pain-regulating mechanisms. Magnetic Resonance Imaging (MRI) offers an objective and visual means to study how the brain orchestrates the characteristics of analgesic effects. From the perspective of multimodal MRI, the investigators applied functional MRI (fMRI) and Magnetic Resonance Spectrum (MRS) techniques to comprehensively evaluate the characteristics of the effects of SMT on the brain region of LDH from the aspects of brain structure, brain function and brain metabolism. This multimodal MRI technique provides a biological basis for the clinical application of SMT in LDH.

Publications & conference data

2 peer-reviewed publications reference this trial (live from Europe PMC):

Impact of Spinal Manipulative Therapy on Brain Function and Pain Alleviation in Lumbar Disc Herniation: A Resting-State fMRI Study.
Zhou XC, Wu S, Wang KZ, Chen LH, et al · · 2025 · cited 5× · PMID 39707137 · DOI 10.1007/s11655-024-4205-7
Default mode network and dorsal attentional network connectivity changes as neural markers of spinal manipulative therapy in lumbar disc herniation.
Zhou XC, Wu S, Wang KZ, Chen LH, et al · · 2024 · cited 3× · PMID 39604454 · DOI 10.1038/s41598-024-81126-2

Verify or expand the search:

Other trials of Spinal Manipulative Therapy

Trials testing the same drug.

NCT05996991 — The Impact of Positive, Neutral and Negative Expectation Speech on Manipulative Therapy Effects · NA · unknown
NCT05202704 — Investigating the Hypoalgesic Effects of Manipulative Therapy Using Pain Conditioning and Expectations in Low Back Pain · NA · unknown
NCT03361592 — The Immediate Effects of Spinal Manipulative Therapy on Kinetic and Kinematic Symmetry. · NA · completed

Other recruiting trials for Lumbar Disc Herniation

Currently open trials in the same condition.

NCT07349719 — Dynamic Compliance-Guided Ventilation in Lumbar Surgery · NA · recruiting
NCT07293676 — IASTM and Vibration Effects on Pain, Functionality, and Kinesiophobia in Lumbar Disc Herniation · NA · recruiting
NCT07184554 — Lumbar Disc Hernia, Erector Spinae Plane Block, Ilesi · NA · recruiting
NCT06853132 — Baduanjin With Resistance Training Program · NA · recruiting
NCT07085247 — The Role of Cutibacterium Acnes in the Development of Degenerative Lumbar Intervertebral Disc Disease · recruiting

Other Zhou Xingchen trials

Trials by the same sponsor.

NCT06318156 — Exploring the Distribution Patterns and Infrared Characteristics of Force-sensitive Acupoints in Different Lumbar Nerve · NA · completed

Verify against primary sources

ClinicalTrials.gov — authoritative US registry record
WHO ICTRP — international registry index
EU Clinical Trials Register
Sponsor press releases (Google)

Data sources for this page

Trial protocol + status: ClinicalTrials.gov NCT06277739 (US National Library of Medicine, public domain)
Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
Sponsor: as reported to ClinicalTrials.gov by Zhou Xingchen
Last refreshed: 15 June 2025

Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT06277739.

Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing