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Effect of Silymarin Against Methotrexate-induced Liver Injury in Rheumatic Diseases, a Double-blind Randomized Controlled Trial
To study the effect of silymarin against methotrexate-induced liver injury in rheumatic diseases including rheumatoid arthritis, psoriatric arthritis and psoriasis
Details
| Lead sponsor | Phramongkutklao College of Medicine and Hospital |
|---|---|
| Phase | NA |
| Status | UNKNOWN |
| Enrolment | 72 |
| Start date | 2024-02-01 |
| Completion | 2025-04 |
Conditions
- Rheumatoid Arthritis
- Psoriatic Arthritis
- Psoriasis
Interventions
- Silymarin
- Placebo
Primary outcomes
- AST or ALT > 1X ULN ( normal AST and ALT 0-50 U/L) — 12 weeks
elevation of AST or ALT more than 1X ULN (% participant)
Countries
Thailand