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NCT06274658
The Effects of an Acute High-intensity Exercise on Heart and Brain Function in People With Spinal Cord Injury
trial testing High-intensity interval exercise in Autonomic Nervous System Disease in 30 participants. Completed in 31 July 2025.
30 June 2025
Quick facts
| Lead sponsor | State University of New York at Buffalo |
|---|---|
| Status | Completed |
| Study type | OBSERVATIONAL |
| Enrollment | 30 |
| Start date | 14 February 2024 |
| Primary completion | 30 June 2025 |
| Estimated completion | 31 July 2025 |
| Sites | 1 location across United States |
Drugs / interventions tested
- High-intensity interval exercise
Conditions studied
- Autonomic Nervous System Disease — all drugs for Autonomic Nervous System Disease →
- Spinal Cord Injuries — all drugs for Spinal Cord Injuries →
- Cognition — all drugs for Cognition →
Sponsor
State University of New York at Buffalo
Who can join
Adults 18 to 70, any sex, with Autonomic Nervous System Disease or Spinal Cord Injuries. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
The heart and brain are regulated by the autonomic nervous system. Control of these organs can be disrupted in people with spinal cord injury (SCI). This may affect their ability to regulate blood pressure during daily activities and process the high-level information. Previous studies show that high-intensity exercise induces better outcomes on heart and information processing ability in non-injured people compared to moderate-intensity exercise. However, it is unknown the effects of high-intensity exercise on heart and brain function in people with SCI. Therefore, this study aims to examine the effects of a single bout of high-intensity interval training on heart and brain function in this people with SCI compared to age- and sex-matched non-injured controls.
Publications & conference data
1 peer-reviewed publication reference this trial (live from Europe PMC):
-
Effects of a single bout of high-intensity-interval exercise on cardiovascular autonomic, cerebrovascular, and cognitive function in people with spinal cord injury: A study protocol.
Ji W, Wecht JM, Jo HJ, Stefanovic F, et al · · 2025 · PMID 40591703 · DOI 10.1371/journal.pone.0326861
Verify or expand the search:
- PubMed search for NCT06274658
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
Related trials
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Trials testing the same drug.
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- NCT03570216 — Cardiovascular Effects of Acute Exercise Post-Stroke · NA · completed
Other recruiting trials for Autonomic Nervous System Disease
Currently open trials in the same condition.
- NCT05212129 — Auricular Vagal Nerve Stimulation for Hypermobile Ehlers-Danlos Syndrome · NA · recruiting
Other State University of New York at Buffalo trials
Trials by the same sponsor.
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- NCT07140848 — CGM-Enhanced DPP to Prevent Type 2 Diabetes in Adults With Prediabetes · NA · not yet recruiting
- NCT07433959 — Neuromodulation to Improve Grasping Function After SCI · NA · not yet recruiting
- NCT07403539 — Speech Learning and Speech Production in Parkinson's Disease · NA · recruiting
- NCT05367362 — Minocycline Efficacy in Improving Neurological Outcome of Patients Who Undergo Endovascular Revascularization for Acute · Phase 2 · withdrawn
Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT06274658 (US National Library of Medicine, public domain)
- Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by State University of New York at Buffalo
- Last refreshed: 3 September 2025
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT06274658.
Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing