NCT06270251

Modeling Tic Change During Behavior Therapy for Tics

Recruiting now NA Last updated 19 March 2026

What this trial tests

NA trial testing CBIT in Chronic Tic Disorder in 30 participants. Currently enrolling.

Timeline

1 March 2024

Primary endpoint
1 March 2028

1 September 2028

Quick facts

Lead sponsor	University of Minnesota
Phase	NA
Status	Recruiting now
Study type	INTERVENTIONAL
Allocation	na
Design	single group
Masking	none
Primary purpose	treatment
Enrollment	30
Start date	1 March 2024
Primary completion	1 March 2028
Estimated completion	1 September 2028
Sites	1 location across United States

Drugs / interventions tested

• CBIT

Conditions studied

• Chronic Tic Disorder — all drugs for Chronic Tic Disorder →

Sponsor

University of Minnesota

Who can join

Adults 12 to 21, any sex, with Chronic Tic Disorder. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

Chronic tics are a disabling neuropsychiatric symptom associated with multiple child-onset mental disorders. Chronic tics affect 1-3% of youth and can be associated with impaired functioning, emotional and behavioral problems, physical pain, diminished quality of life, and peer victimization. Chronic tics are the primary symptom of Tourette Syndrome (TS) and Persistent Motor/Vocal Tic Disorders.

CBIT is a manualized treatment focused on increasing tic controllability. Its core procedure is competing response training (CRT), in which patients learn to inhibit tics by learning and applying a competing motor action to one tic at a time. CBIT is recommended as a first-line treatment relative to medications and other therapies. However, only 52% of children and 38% of adults show clinically meaningful tic improvement. Large randomized trials have demonstrated the superiority of CBIT over supportive therapy in child and adult patients, and meta-analysis shows comparable effect sizes for CBIT and medication. Although increasing tic controllability is the primary goal of CBIT, tic controllability nor its correlates have been examined longitudinally during the intervention.

The overall objective of this study is to use fine-grained data collection strategies to identify patterns in tic controllability and other relevant related variables that are associated with treatment response to CBIT. Participants with chronic tics will complete a manualized course of 8-session CBIT. Behavioral, psychosocial, and global functioning will be assessed longitudinally to examine predictors and correlates of response. CBIT sessions will be video recorded.

Publications & conference data

No peer-reviewed publications indexed yet for this trial.