Last reviewed · How we verify
NCT06261515
Multi-omics Analysis of Oral-gut Microbial Profiles
NA trial testing Active periodontal treatment in Periodontitis in 70 participants. Currently enrolling.
15 January 2026
Quick facts
| Lead sponsor | University of Turin, Italy |
|---|---|
| Phase | NA |
| Status | Recruiting now |
| Study type | INTERVENTIONAL |
| Allocation | na |
| Design | single group |
| Masking | none |
| Primary purpose | treatment |
| Enrollment | 70 |
| Start date | 15 February 2024 |
| Primary completion | 15 January 2026 |
| Estimated completion | 15 February 2026 |
| Sites | 1 location across Italy |
Drugs / interventions tested
- Active periodontal treatment
Conditions studied
- Periodontitis — all drugs for Periodontitis →
Sponsor
University of Turin, Italy
Who can join
18 and older, any sex, with Periodontitis. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
Periodontitis is a chronic inflammatory disease of the tooth supporting structures induced by a dysbiosis in the oral and subgingival microenvironment of susceptible patients. The long-term swallowing of high doses of periodontal pathogenic microorganisms could induce a dysbiosis of the intestinal microbiota, favouring the establishment of an 'inflamed' microbiome in terms of composition and/or function. The present project is aimed at a better understanding of the etiopathogenetic correlation between periodontitis and intestinal dysbiosis, and aims to explore the hypothesis that periodontal treatment may influence the multi-omics profile on the oral-gut-systemic axis. 70 patients affected by stage III-IV periodontitis will be recruited, and treated by means of full-mouth scaling and root planing. Salivary, subgingival plaque, plasma and stool samples, together with a complete periodontal charting and a food diary will be collected and compared at baseline and after treatment. Age, gender and BMI-matched healthy individuals will be recruited as controls.
Publications & conference data
No peer-reviewed publications indexed yet for this trial.
Verify or expand the search:
- PubMed search for NCT06261515
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
Related trials
Other recruiting trials for Periodontitis
Currently open trials in the same condition.
- NCT07463859 — Effects of Periodontal Treatment Associated With Antimicrobial Photodynamic Therapy on Halitosis in Patients With Diabet · NA · recruiting
- NCT07535177 — Gas6 and Soluble MerTK in Periodontal Diseases · recruiting
- NCT07491848 — Oral-Periodontal Evaluation and Assessment of Oral Fluid Biomarkers in Patients With Hepatitis B+D · recruiting
- NCT07421960 — Investigation of the Relationship Between Periodontitis and Sleep Quality · recruiting
- NCT07532694 — Diode Laser-Assisted Periodontal Therapy in Kidney Transplant Recipients · NA · recruiting
Other University of Turin, Italy trials
Trials by the same sponsor.
- NCT06493188 — Low VS High-fidelity Interprofessional Simulation for ABG Skills Acquisition · NA · not yet recruiting
- NCT07418489 — Biotics Intervention Oriented to Rescue From Environmental Pollution Inflammatory Responses · NA · enrolling by invitation
- NCT07311291 — The Effect of Different Hemostatic Agents on Hemorrhage Control, Pain and Quality of Life After Endodontic Microsurgery. · NA · completed
- NCT06904963 — Efficacy of Oral Hygiene Instructions Carried Out Using an Intra-oral Scanner · NA · completed
- NCT07047261 — Efficacy of a Xanthan-based Chlorhexidine Gel in the Treatment of Peri-implant Mucositis · NA · recruiting
Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT06261515 (US National Library of Medicine, public domain)
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by University of Turin, Italy
- Last refreshed: 31 May 2024
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT06261515.
Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing