NCT06259357: P-POD

Prone Positioning in Neurologically Deceased Potential Organ Donors to Improve Donor Lung Function and Lung Transplant Recipient Outcomes

Not yet recruiting NA Last updated 4 December 2024

What this trial tests

NA trial testing Protocolized protective mechanical ventilation in prone position in Lung Transplant Failure in 40 participants. Not yet recruiting.

Timeline

2 January 2025

Primary endpoint
1 August 2025

1 August 2026

Quick facts

Lead sponsor	Lorenzo delSorbo
Phase	NA
Status	Not yet recruiting
Study type	INTERVENTIONAL
Allocation	randomized
Design	parallel
Masking	none
Primary purpose	other
Enrollment	40
Start date	2 January 2025
Primary completion	1 August 2025
Estimated completion	1 August 2026
Sites	1 location across Canada

Drugs / interventions tested

• Protocolized protective mechanical ventilation in prone position

Conditions studied

• Lung Transplant Failure — all drugs for Lung Transplant Failure →

Sponsor

Lorenzo delSorbo — full company profile →

Who can join

18 and older, any sex, with Lung Transplant Failure. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

The purpose of this study is to determine the practicality of performing a future, large-scale study. The future study will look at the effect of mechanical ventilation in neurologically deceased (brain-dead) lung donors who are positioned to lay flat on their stomach (prone position), compared to donors who are positioned to lay flat on their back (supine position). The study will also look at the potential impact of prone positioning of the donor on transplant recipients of the study organs.

The investigators are doing this study because the investigators want to increase the availability of donor lungs for lung transplant. Lung transplant is a life-saving treatment for individuals with lung disease, but there are not enough donated lungs to meet demand. Researchers are looking for better ways of preventing donated lungs from becoming unsuitable for transplant. Because of this, the goal of our study is to test whether prone positioning in neurologically deceased (brain-dead) lung donors can improve donor lung function and decrease complications, potentially increasing the number of donor lungs that can be used for transplant.

Publications & conference data

1 peer-reviewed publication reference this trial (live from Europe PMC):

1. Contemporary evidence to inform management of deceased potential thoracic organ donors after brain death.
   Ciardi F, Magri C, Rubino A, Vail EA. · · 2026 · PMID 41583417 · DOI 10.1016/j.jhlto.2025.100474