Last reviewed · How we verify
NCT06256146: IMPROVES
Investigating Modified Protocols of Oral Immunotherapy to Validate Efficacy and Safety
NA trial testing Food allergy desensitization / Oral Immunotherapy in Peanut Allergy in 360 participants. Currently enrolling.
28 February 2030
Quick facts
| Lead sponsor | McGill University Health Centre/Research Institute of the McGill University Health Centre |
|---|---|
| Phase | NA |
| Status | Recruiting now |
| Study type | INTERVENTIONAL |
| Allocation | randomized |
| Design | parallel |
| Masking | none |
| Primary purpose | treatment |
| Enrollment | 360 |
| Start date | 1 March 2022 |
| Primary completion | 28 February 2030 |
| Estimated completion | 28 February 2030 |
| Sites | 1 location across Canada |
Drugs / interventions tested
- Food allergy desensitization / Oral Immunotherapy
Conditions studied
- Peanut Allergy — all drugs for Peanut Allergy →
- Milk Allergy, Cow's — all drugs for Milk Allergy, Cow's →
- Egg Allergy — all drugs for Egg Allergy →
Sponsor
McGill University Health Centre/Research Institute of the McGill University Health Centre
Who can join
Adults 2 to 40, any sex, with Peanut Allergy or Milk Allergy, Cow's. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
Protocols for Oral Immunotherapy (OIT) for the main food allergens have been recently incorporated in clinical practice for food allergies and their clinical benefits have been acknowledged in European and Canadian official guidelines. There has been some reluctance in both clinicians and patients to implement these therapies, primarily because of the risk of allergic reactions during the desensitization process. This study will investigate if protocols using low doses of a food allergen or processed versions of the allergen can be both effective in conferring desensitization while inducing fewer allergic symptoms during the desensitization process.
Publications & conference data
No peer-reviewed publications indexed yet for this trial.
Verify or expand the search:
- PubMed search for NCT06256146
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
Related trials
Other recruiting trials for Peanut Allergy
Currently open trials in the same condition.
- NCT07349212 — UKK-0018 as an Immunotherapeutic for Treatment of Peanut Allergies · Phase 1, PHASE2 · recruiting
- NCT05695261 — Evaluating the Safety and Efficacy of Oral Encapsulated Microbiota Transplantation Therapy in Peanut Allergic Patients · Phase 2 · recruiting
- NCT05503446 — Using Commonly Available Food Products To Treat Food Allergy · NA · active not recruiting
- NCT05667610 — Immune-supportive Diet and Gut Permeability in Allergic Children · NA · recruiting
- NCT03532360 — Peanut and Tree Nut Desensitization · NA · active not recruiting
Other McGill University Health Centre/Research Institute of the McGill University Health Centre trials
Trials by the same sponsor.
- NCT07439406 — Comparing Standard and Autoclaved Peanut Oral Immunotherapy in People With Peanut Allergy · Phase 2 · not yet recruiting
- NCT07328971 — Vancomycin Taper to Prevent Recurrent Clostridioides Difficile · Phase 3 · not yet recruiting
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- NCT07069582 — Pharmacokinetics of Antituberculosis Drugs in Breastfeeding Women · Phase 1 · not yet recruiting
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Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT06256146 (US National Library of Medicine, public domain)
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by McGill University Health Centre/Research Institute of the McGill University Health Centre
- Last refreshed: 9 February 2026
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT06256146.
Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing