NCT06250842 is a clinical trial in Benzodiazepine Adverse Reaction, sponsored by The First Affiliated Hospital of Dalian Medical University.

Who is sponsoring NCT06250842?

NCT06250842 is sponsored by The First Affiliated Hospital of Dalian Medical University.

What condition does NCT06250842 study?

NCT06250842 studies Benzodiazepine Adverse Reaction, Depression, Anxiety, Benzodiazepine Dependence.

Is NCT06250842 still recruiting?

NCT06250842 is currently recruiting now. Last updated 11 April 2025.

Last reviewed 2025-04-11 · How we verify

NCT06250842

Name: Drug Landscape Pharmaceutical Database
Creator: Drug Landscape
Published: 2026-01-01
License: https://creativecommons.org/licenses/by/4.0/

Benzodiazepine Impact on Cognitive Function: fNIRs and PET/MRI Study

Recruiting now Last updated 11 April 2025

What this trial tests

trial in Benzodiazepine Adverse Reaction in 100 participants. Currently enrolling.

Timeline

11 February 2024

Primary endpoint
20 February 2027

30 June 2027

Quick facts

Lead sponsor	The First Affiliated Hospital of Dalian Medical University
Status	Recruiting now
Study type	OBSERVATIONAL
Enrollment	100
Start date	11 February 2024
Primary completion	20 February 2027
Estimated completion	30 June 2027
Sites	1 location across China

Conditions studied

Benzodiazepine Adverse Reaction — all drugs for Benzodiazepine Adverse Reaction →
Depression, Anxiety — all drugs for Depression, Anxiety →
Benzodiazepine Dependence — all drugs for Benzodiazepine Dependence →

Sponsor

The First Affiliated Hospital of Dalian Medical University

Who can join

Adults 18 to 80, any sex, with Benzodiazepine Adverse Reaction or Depression, Anxiety. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

This study explores the impact of long-term benzodiazepine (BZDs) use on cognitive function and associated neuroimaging markers. While BZDs are established treatments for conditions like anxiety and insomnia, recent warnings highlight risks, including neurocognitive effects. Neuroimaging studies indicate potential neuroprotective effects of BZDs. Functional near-infrared spectroscopy (fNIRS) measures cerebral cortex function during cognitive tasks. Combining fNIRS with mood and cognitive scales, this study assesses cortical activation. 2-deoxy-2-fluoro-D-glucose-positron emission tomography (FDG-PET) evaluates brain metabolism. DPA-714 PET assesses neuroinflammation. The primary objective is to compare brain functional activation, metabolism, and neuroinflammatory levels between long-term BZD users and non-users. This comprehensive approach aims to provide insights into BZD effects on cognition and associated brain markers.

Publications & conference data

1 peer-reviewed publication reference this trial (live from Europe PMC):

Enhanced interhemispheric functional connectivity in elderly anxiety patients with long-term benzodiazepine use: an fNIRS study.
Chang Y, Liu M, Liu Y, Xie X, et al · · 2026 · PMID 41656398 · DOI 10.1038/s41598-026-39359-w

Verify or expand the search:

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Verify against primary sources

ClinicalTrials.gov — authoritative US registry record
WHO ICTRP — international registry index
EU Clinical Trials Register
Sponsor press releases (Google)

Data sources for this page

Trial protocol + status: ClinicalTrials.gov NCT06250842 (US National Library of Medicine, public domain)
Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
Sponsor: as reported to ClinicalTrials.gov by The First Affiliated Hospital of Dalian Medical University
Last refreshed: 11 April 2025

Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT06250842.

Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing