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NCT06250114
Retreat or Replace: Retrospective Investigation on a Cohort of Local Patients
trial testing Retreatment in Endodontic Disease in 130 participants. Completed in 12 July 2023.
12 January 2023
Quick facts
| Lead sponsor | University of Bologna |
|---|---|
| Status | Completed |
| Study type | OBSERVATIONAL |
| Enrollment | 130 |
| Start date | 12 January 2008 |
| Primary completion | 12 January 2023 |
| Estimated completion | 12 July 2023 |
Drugs / interventions tested
- Retreatment
- extraction implant
Conditions studied
- Endodontic Disease — all drugs for Endodontic Disease →
- Dental Implant Failed — all drugs for Dental Implant Failed →
- Periapical Diseases — all drugs for Periapical Diseases →
Sponsor
University of Bologna
Who can join
Adults 18 to 75, any sex, with Endodontic Disease or Dental Implant Failed. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
Introduction: To evaluate the survival and success rate of premolars with a previous root canal treatment which underwent to non-surgical retreatment or to extraction and implant replacement. Materials and methods: Patients visiting in the Clinical Endodontic Section of the School of Dentistry (University of Bologna) were eligible for the study. Out of these patients, those with previously root canal treated premolars fulfilled the inclusion criteria. Teeth were considered retreatable and restorable (Endo group) or not retreatable and not restorable (Implant group) on the basis of clinical and radiographical examination. Each patient was included in an annual recall programme and final evaluation was performed after 8 years. Clinical parameters were recorded. Differences in baseline characteristics between the two treatment groups were assessed using logistic regression analysis with clustered standard errors. Results were expressed for each variable as odds ratios (ORs) of implant rehabilitation to root canal retreatment with 95% confidence intervals (CIs). Survival and treatment success for the two study groups were estimated using the Kaplan-Meier method. The association of treatment group with time to event was assessed using Cox proportional hazard regression analysis with clustered standard errors to allow for intragroup correlation within teeth belonging to the same patient. Results were expressed as hazard ratios (HRs) of experiencing the study event among implants as compared to root canal retreatments with 95% CIs.
Publications & conference data
1 peer-reviewed publication reference this trial (live from Europe PMC):
-
Retreatment or replacement of previous endodontically treated premolars with recurrent apical periodontitis? An 8-year historical cohort study.
Zamparini F, Spinelli A, Lenzi J, Peters OA, et al · · 2025 · cited 2× · PMID 40074937 · DOI 10.1007/s00784-025-06238-z
Verify or expand the search:
- PubMed search for NCT06250114
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
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Trials testing the same drug.
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Other recruiting trials for Endodontic Disease
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Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT06250114 (US National Library of Medicine, public domain)
- Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by University of Bologna
- Last refreshed: 8 February 2024
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT06250114.
Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing